YL001_YEAST
ID YL001_YEAST Reviewed; 862 AA.
AC Q07895; D6VY03;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=FAS1 domain-containing protein YLR001C;
DE Flags: Precursor;
GN OrderedLocusNames=YLR001C; ORFNames=L1388;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 90840 / EAY235 / FY23;
RX PubMed=8810043;
RX DOI=10.1002/(sici)1097-0061(19960615)12:7<693::aid-yea956>3.0.co;2-g;
RA Miosga T., Zimmermann F.K.;
RT "Sequence analysis of the CEN12 region of Saccharomyces cerevisiae on a
RT 43.7 kb fragment of chromosome XII including an open reading frame
RT homologous to the human cystic fibrosis transmembrane conductance regulator
RT protein CFTR.";
RL Yeast 12:693-708(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000305}; Single-pass type
CC I membrane protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 206 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X91488; CAA62770.1; -; Genomic_DNA.
DR EMBL; Z73173; CAA97523.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09319.1; -; Genomic_DNA.
DR PIR; S64821; S64821.
DR RefSeq; NP_013101.1; NM_001181888.1.
DR AlphaFoldDB; Q07895; -.
DR SMR; Q07895; -.
DR BioGRID; 31274; 25.
DR DIP; DIP-4383N; -.
DR IntAct; Q07895; 1.
DR MINT; Q07895; -.
DR STRING; 4932.YLR001C; -.
DR SwissPalm; Q07895; -.
DR MaxQB; Q07895; -.
DR PaxDb; Q07895; -.
DR PRIDE; Q07895; -.
DR EnsemblFungi; YLR001C_mRNA; YLR001C; YLR001C.
DR GeneID; 850687; -.
DR KEGG; sce:YLR001C; -.
DR SGD; S000003991; YLR001C.
DR VEuPathDB; FungiDB:YLR001C; -.
DR eggNOG; KOG1437; Eukaryota.
DR GeneTree; ENSGT00530000063860; -.
DR HOGENOM; CLU_008441_0_0_1; -.
DR InParanoid; Q07895; -.
DR OMA; FCSSNKR; -.
DR BioCyc; YEAST:G3O-32162-MON; -.
DR PRO; PR:Q07895; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q07895; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR Gene3D; 2.30.180.10; -; 2.
DR InterPro; IPR036378; FAS1_dom_sf.
DR InterPro; IPR000782; FAS1_domain.
DR Pfam; PF02469; Fasciclin; 2.
DR SUPFAM; SSF82153; SSF82153; 4.
DR PROSITE; PS50213; FAS1; 3.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix; Vacuole.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..862
FT /note="FAS1 domain-containing protein YLR001C"
FT /id="PRO_0000247181"
FT TOPO_DOM 24..762
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 763..783
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 784..862
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 34..162
FT /note="FAS1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00082"
FT DOMAIN 463..604
FT /note="FAS1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00082"
FT DOMAIN 606..744
FT /note="FAS1 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00082"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 291
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 333
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 450
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 521
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 542
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 569
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 663
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 679
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 688
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 862 AA; 97618 MW; 5AD3E25DD69E13A1 CRC64;
MNMAIQTIKY IFWLLPILGL TQALLQNPGD DFPFSTVIDI LSENVEFSTF LRIIQKTGHV
QYLNELQNFT LFAPINSAFI KGDQTTDQFE EHFHIEDFLI HDRVLQVRDL ENGTYLEKRA
AKAPLLLRKH ERHCFVNEIA VVEPDLLPSF QNASLQGINN LLLIQPQINE LLVQLDEETQ
DLKIFSDFIS SFSNYNAYTN SSTVLVPLDV NFRKFFNTIE INYLLDKYNK LGKSNTISQA
KWAADRTSLL QELIIDDVYG GILPKELILE NKNNRKLFMK SNSEGTSVSV NNSDYSPISN
RIFEIGVVHG FSDLDFLRTH IQFDAEKYLH GLNCSEFVKE LYFRDLEKFI QNGRKITIFV
PQASFNEDRG YTKPSLLYHF VEGKIDLEQD FSSLRPIQYA PTQIYDSAFC SSAKRLGGHC
QKFKITRSNK GYYINGRFKI LNTKPYEIGN TSIYSIDDDL QLPGDLVLSL APENHCSISL
MLLKELNLLD LPSNHKGYTI LLPCMNSWDN NDLTIDYLRS NKTALNLLMR NLIFEDLIYS
NNYSISTTVK NLYGNSVSIG VQKIVGSQNL TKISVSTIKE SIIIEESSDI FFNQGVIHPI
DQLDFPVDLE ISLKELIETT GTKEIFDFFN LFYDLSSIIW NNEEYSLLVP TASSIPLSGI
TANSTNLRKF LELHLIPANV TQNLLDCNGS ISTKLGTKLN CRKDHLDNVF VSIQGDWTKE
VRVLKTGCTT NLKSSCIFLI DKPISLSWLN SEKYHLRLPG IAVGFGVIIG VTIAISLLFC
IIITRGGKVK DKNQRGRNDR ATTPLIQHSP IIHNPSYSAT AHLSPLSQPT FEGSYSVNAI
QTPRDIRRVG SDQKGGRSVS TS
