CBIQ_SALTY
ID CBIQ_SALTY Reviewed; 225 AA.
AC Q05598;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Cobalt transport protein CbiQ;
DE AltName: Full=Energy-coupling factor transporter transmembrane protein CbiQ;
DE Short=ECF transporter T component CbiQ;
GN Name=cbiQ; OrderedLocusNames=STM2021;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=LT2;
RX PubMed=8501034; DOI=10.1128/jb.175.11.3303-3316.1993;
RA Roth J.R., Lawrence J.G., Rubenfield M., Kieffer-Higgins S., Church G.M.;
RT "Characterization of the cobalamin (vitamin B12) biosynthetic genes of
RT Salmonella typhimurium.";
RL J. Bacteriol. 175:3303-3316(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP FUNCTION IN COBALT TRANSPORT, SUBSTRATES, SUBUNIT, AND EXPRESSION IN
RP E.COLI.
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=16352848; DOI=10.1128/jb.188.1.317-327.2006;
RA Rodionov D.A., Hebbeln P., Gelfand M.S., Eitinger T.;
RT "Comparative and functional genomic analysis of prokaryotic nickel and
RT cobalt uptake transporters: evidence for a novel group of ATP-binding
RT cassette transporters.";
RL J. Bacteriol. 188:317-327(2006).
CC -!- FUNCTION: Part of the energy-coupling factor (ECF) transporter complex
CC CbiMNOQ involved in cobalt import. The complex confers cobalt uptake
CC upon expression in E.coli; can also transport nickel with a very low
CC affinity. {ECO:0000269|PubMed:16352848}.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC -!- SUBUNIT: Forms an energy-coupling factor (ECF) transporter complex
CC composed of an ATP-binding protein (A component, CbiO), a transmembrane
CC protein (T component, CbiQ) and 2 possible substrate-capture proteins
CC (S components, CbiM and CbiN) of unknown stoichimetry. Expression of
CC just CbiMN in E.coli confers some cobalt uptake.
CC {ECO:0000269|PubMed:16352848}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CbiQ family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L12006; AAA27266.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20925.1; -; Genomic_DNA.
DR RefSeq; NP_460966.1; NC_003197.2.
DR RefSeq; WP_000147137.1; NC_003197.2.
DR AlphaFoldDB; Q05598; -.
DR SMR; Q05598; -.
DR STRING; 99287.STM2021; -.
DR TCDB; 3.A.1.23.6; the atp-binding cassette (abc) superfamily.
DR PaxDb; Q05598; -.
DR EnsemblBacteria; AAL20925; AAL20925; STM2021.
DR GeneID; 1253542; -.
DR KEGG; stm:STM2021; -.
DR PATRIC; fig|99287.12.peg.2143; -.
DR HOGENOM; CLU_056469_5_3_6; -.
DR OMA; IAMMMYR; -.
DR PhylomeDB; Q05598; -.
DR BioCyc; SENT99287:STM2021-MON; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006824; P:cobalt ion transport; IDA:UniProtKB.
DR InterPro; IPR003339; ABC/ECF_trnsptr_transmembrane.
DR InterPro; IPR012809; ECF_CbiQ.
DR Pfam; PF02361; CbiQ; 1.
DR TIGRFAMs; TIGR02454; ECF_T_CbiQ; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Cobalamin biosynthesis; Cobalt;
KW Cobalt transport; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..225
FT /note="Cobalt transport protein CbiQ"
FT /id="PRO_0000089376"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 71
FT /note="G -> R (in Ref. 1; AAA27266)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 225 AA; 25884 MW; BD90994FD10833B3 CRC64;
MTGLDRLSYQ SRWAHVAPQR KFLLWLAMMI LAFVLPPVGQ GIELLIIAGL SCWLLRISLW
RWCRWMAIPF GFLLVGVITI IFSISREPQM LLAGISVGPY WIGITRAGVV TANETFWRSL
TALSATLWLV MNLPFPQLIS LLKRAHIPRL LTEQILLTWR FLFILLDEAV AIRRAQTLRF
GYCSLPNGYR SLAMLAGLLF TRVLMRYQQM TTTLDIKLYQ GDFHL
