YL054_YEAST
ID YL054_YEAST Reviewed; 843 AA.
AC Q12244; D6VXV4;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Uncharacterized transcriptional regulatory protein YLL054C;
GN OrderedLocusNames=YLL054C; ORFNames=L0584;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 768.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION.
RX PubMed=11353088; DOI=10.1093/nar/29.10.2181;
RA Akache B., Wu K., Turcotte B.;
RT "Phenotypic analysis of genes encoding yeast zinc cluster proteins.";
RL Nucleic Acids Res. 29:2181-2190(2001).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ADR376;
RX PubMed=17330950; DOI=10.1021/pr060559j;
RA Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,
RA Elias J.E., Gygi S.P.;
RT "Large-scale phosphorylation analysis of alpha-factor-arrested
RT Saccharomyces cerevisiae.";
RL J. Proteome Res. 6:1190-1197(2007).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- FUNCTION: Required for growth on non-fermentable carbon sources.
CC {ECO:0000269|PubMed:11353088}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAT92638.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA88003.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA97507.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; Z47973; CAA88003.1; ALT_FRAME; Genomic_DNA.
DR EMBL; Z73159; CAA97507.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AY692619; AAT92638.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BK006945; DAA09270.2; -; Genomic_DNA.
DR PIR; S50966; S50966.
DR RefSeq; NP_013046.2; NM_001181874.2.
DR AlphaFoldDB; Q12244; -.
DR BioGRID; 31261; 47.
DR DIP; DIP-5612N; -.
DR IntAct; Q12244; 1.
DR STRING; 4932.YLL054C; -.
DR iPTMnet; Q12244; -.
DR MaxQB; Q12244; -.
DR PaxDb; Q12244; -.
DR PRIDE; Q12244; -.
DR EnsemblFungi; YLL054C_mRNA; YLL054C; YLL054C.
DR GeneID; 850672; -.
DR KEGG; sce:YLL054C; -.
DR SGD; S000003977; YLL054C.
DR VEuPathDB; FungiDB:YLL054C; -.
DR eggNOG; ENOG502RJ72; Eukaryota.
DR GeneTree; ENSGT00940000176335; -.
DR HOGENOM; CLU_015392_0_0_1; -.
DR InParanoid; Q12244; -.
DR BioCyc; YEAST:G3O-32153-MON; -.
DR PRO; PR:Q12244; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q12244; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:SGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..843
FT /note="Uncharacterized transcriptional regulatory protein
FT YLL054C"
FT /id="PRO_0000247135"
FT DNA_BIND 15..42
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ SEQUENCE 843 AA; 97610 MW; F03F8237481BE260 CRC64;
MSIASQKKVK PSFVCLRCKQ RKIKCDKLWP TCSKCKASSS ICSYEVEPGR INKSPTIENA
PHRDIRNITP ASMSASGSFT SILNPSTKDW EMKNFAMNLS NAHDKLVVMN NTTIVDSPFA
FHSILQHDLY AKALTTCIHE RILIDVERHR ENVSANNKKR ELNLTIGDIG PLFFIDKAAL
KFIENTSKTS KLYPPIDFLY NTYDYEQAHP EENNDKISIN ILLEELSKYF LNKNEVDGLI
VDFYKTIYPV YPLLEISLFE DNIRELLQLN EFNGYNIVFA GKDSRRKLET ITLLTIILAF
SYRRLSLSTS HSFKESFGVK SNNLTLLAHK LLALMNVFQY VNEHTLCCLL YFFILRYLNP
DQADMYPTHS DILNLKFLEN VAIKLGLNEE PFQYTRYVSE SDDYPRLFNL RRKLWLGVQF
LKFGILIPEG DSDILSLEYL RSFMKTDESL PELFERNYAS TNNLDLSLMA TAENIYHLHL
SLQVLLTSCF PINGPSYLKE VLDNIDKTKD FLNQKFPLIL SSLGEPRMKS LHINVPSSLA
NEESFDFSTF EENETFIANV ISYTCTMNIY DSLSLHFENQ CFKNALEYKT YYHRFTFTAI
QDYLTLLKLI SEYFNGSLLH LREPFGFATQ KVVRFSIHRL LIFQATLLVR LFYKKDTCDR
SSAAMGMLND RNGRLSRVIE KMIKLMSYHM KLLVEIVISK LEKSYLGSFI SVSIFRYIIY
LVDTDALSAF ISDYWKSDAV MDERYSRIHR IVGLKWGMGR DKSFSFTSKL NNPQFLGSLD
LEILEELEKL ISAQEFSRNF TEDVDESLQS EIDLMNYDNE ALNQLMAIDL DKLLGIFPNL
SNF
