YL066_YEAST
ID YL066_YEAST Reviewed; 1374 AA.
AC Q99208; D6VXU4; Q12054;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Y' element ATP-dependent helicase YLL066C;
DE EC=3.6.4.12;
GN OrderedLocusNames=YLL066C; ORFNames=L0519, L0532;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RA Wedler H., Wambutt R.;
RT "Sequence of a 37 kb DNA fragment from chromosome XII of Saccharomyces
RT cerevisiae including the subtelomeric region of the left arm.";
RL Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=9837911; DOI=10.1074/jbc.273.50.33360;
RA Yamada M., Hayatsu N., Matsuura A., Ishikawa F.;
RT "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is
RT induced in survivors defective for telomerase.";
RL J. Biol. Chem. 273:33360-33366(1998).
CC -!- FUNCTION: Catalyzes DNA unwinding and is involved in telomerase-
CC independent telomere maintenance. {ECO:0000269|PubMed:9837911}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- INDUCTION: Induced in absence of telomerase TLC1.
CC {ECO:0000269|PubMed:9837911}.
CC -!- SIMILARITY: Belongs to the helicase family. Yeast subtelomeric Y'
CC repeat subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA87990.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA87991.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAA97520.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=DAA09260.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; Z47973; CAA87990.1; ALT_INIT; Genomic_DNA.
DR EMBL; Z47973; CAA87991.1; ALT_SEQ; Genomic_DNA.
DR EMBL; Z73171; CAA97520.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006945; DAA09260.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_013034.1; NM_001181886.1.
DR AlphaFoldDB; Q99208; -.
DR SMR; Q99208; -.
DR BioGRID; 31251; 3.
DR PeptideAtlas; Q99208; -.
DR GeneID; 850660; -.
DR KEGG; sce:YLL066C; -.
DR SGD; S000003989; YLL066C.
DR BioCyc; YEAST:G3O-32160-MON; -.
DR Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR Reactome; R-SCE-936440; Negative regulators of DDX58/IFIH1 signaling.
DR PRO; PR:Q99208; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q99208; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0004386; F:helicase activity; ISS:SGD.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:UniProt.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR021646; Sir1_ORC-binding.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF11603; Sir1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT CHAIN 1..1374
FT /note="Y' element ATP-dependent helicase YLL066C"
FT /id="PRO_0000268167"
FT DOMAIN 375..552
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 609..758
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 321..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 498..501
FT /note="DEAH box"
FT COMPBIAS 323..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..999
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 388..395
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 1374 AA; 155398 MW; F5EBE027EAA12F9B CRC64;
MKVSDRRKFE KANFDEFESA LNNKNDLVHC PSITLFESIP TEVRSFYEDE KSGLIKVVKF
RTGAMDRKRS FEKIVVSVMV GKNVQKFLTF VEDEPDFQGG PIPSKYLIPK KINLMVYTLF
QVHTLKFNRK DYDTLSLFYL NRGYYNELSF RVLERCHEIA SARPNDSSTM RTFTDFVSGA
PIVRSLQKST IRRYGYNLAP HMFLLLHVDE LSIFSAYQAS LPGEKKVDTE RLKRDLCPRK
PIEIKYFSQI CNDMMNKKDR LGDVLATAQR IRRRYNKNGS SEPRLKTLDG LTSERWIQWL
GLESDYHCSF SSTRNAEDVV AGEAASSDHD QKISRVTRKR PREPKSTNDI LVAGQKLFGS
SFEFRDLHQL RLCHEIYMAD TPSVAVQAPP GYGKTELFHL PLIALASKGD VKYVSFLFVP
YTVLLANCMI RLGRCGCLNV APVRNFIEEG CDGVTDLYVG IYDDLASTNF TDRIAAWENI
VECTFRTNNV KLGYLIVDEF HNFETEVYRQ SQFGGITNLD FDAFEKAIFL SGTAPEAVAD
AALQRIGLTG LAKKSMDINE LKRSEDLSRG LSSYPTRMFN LIKEKSEVPL GHVHKIWKKV
ESQPEEALKL LLALFEIEPE SKAIVVASTT NEVEELACSW RKYFRVVWIH GKLGAAEKVS
RTKEFVTDGS MRVLIGTKLV TEGIDIKQLM MVIMLDNRLN IIELIQGVGR LRDGGLCYLL
SRKNSWAARN RKGELPPIKE GCITEQVREF YGLESKKGKK GQHVGCCGSR TDLSADTVEL
IERMDRLAEK QATASMSIVA LPSSFQESNS SDRCRKYCSS DEDSNTCIHG SANASTNATT
NSSTNATTTA STNVRTSATT TASINVRTSA TTTESTNSST NATTTASTNV RTSATTTASI
NVRTSATTTE STNSNTSATT TESTDSNTSA TTTESTDSNT SATTTASTNS STNATTTAST
NSSTNATTTE STNASAKEDA NKDGNAEDNR FHPVTDINKE SYKRKGSQMV LLERKKLKAQ
FPNTSENMNV LQFLGFRSDE IKHLFLYGID IYFCPEGVFT QYGLCKGCQK MFGLCVCWAG
QKVSYRRMAW EALAVERMLR NDEEYKEYLE DIEPYHGDPV GYLKFFSVKR GEIYSQIQRN
YAWYLAITRR RETISVLDST RGKQGSQVFR MSGRQIKELY YKVWSNLRES KTEVLQYFLN
WDEKKCREEW EAKDDTVFVE ALEKVGVFQR LRSMTSAGLQ GPQYVKLQFS RHHRQLRSRY
ELSLGMHLRD QLALGVTPSK VPHWTAFLSM LIGLFYNKTF RQKLEYLLEQ ISEVWLLPHW
VDLANVEVLA ADNTRVPLYM LMVAVHKELD SDDVPDGRFD IILLCRDSSR EVGE
