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YL067_YEAST
ID   YL067_YEAST             Reviewed;        1374 AA.
AC   Q07888; D6VXU2; E9PAE6; O94145; Q12054;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Y' element ATP-dependent helicase YLL067C;
DE            EC=3.6.4.12;
GN   OrderedLocusNames=YLL067C; ORFNames=L0111, L0503, L0509;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-566.
RC   STRAIN=ATCC 204511 / S288c / AB972;
RA   Wedler H., Wambutt R.;
RT   "Sequence of a 37 kb DNA fragment from chromosome XII of Saccharomyces
RT   cerevisiae including the subtelomeric region of the left arm.";
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=9837911; DOI=10.1074/jbc.273.50.33360;
RA   Yamada M., Hayatsu N., Matsuura A., Ishikawa F.;
RT   "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is
RT   induced in survivors defective for telomerase.";
RL   J. Biol. Chem. 273:33360-33366(1998).
CC   -!- FUNCTION: Catalyzes DNA unwinding and is involved in telomerase-
CC       independent telomere maintenance. {ECO:0000269|PubMed:9837911}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- INDUCTION: Induced in absence of telomerase TLC1.
CC       {ECO:0000269|PubMed:9837911}.
CC   -!- SIMILARITY: Belongs to the helicase family. Yeast subtelomeric Y'
CC       repeat subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA87988.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA87989.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA97521.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAA97522.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=DAA09258.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; Z73171; CAA97521.1; ALT_INIT; Genomic_DNA.
DR   EMBL; Z73172; CAA97522.1; ALT_INIT; Genomic_DNA.
DR   EMBL; Z47973; CAA87988.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; Z47973; CAA87989.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BK006945; DAA09258.1; ALT_INIT; Genomic_DNA.
DR   PIR; S64819; S64819.
DR   RefSeq; NP_013033.1; NM_001181887.1.
DR   AlphaFoldDB; Q07888; -.
DR   BioGRID; 31250; 3.
DR   DIP; DIP-8845N; -.
DR   PeptideAtlas; Q07888; -.
DR   GeneID; 850659; -.
DR   KEGG; sce:YLL067C; -.
DR   SGD; S000003990; YLL067C.
DR   BioCyc; YEAST:G3O-32161-MON; -.
DR   Reactome; R-SCE-5689880; Ub-specific processing proteases.
DR   Reactome; R-SCE-936440; Negative regulators of DDX58/IFIH1 signaling.
DR   PRO; PR:Q07888; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q07888; protein.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004386; F:helicase activity; ISS:SGD.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR021646; Sir1_ORC-binding.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF11603; Sir1; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..1374
FT                   /note="Y' element ATP-dependent helicase YLL067C"
FT                   /id="PRO_0000268168"
FT   DOMAIN          375..552
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          609..758
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          321..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          832..1035
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           498..501
FT                   /note="DEAH box"
FT   COMPBIAS        323..345
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        832..1011
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1012..1035
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         388..395
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   1374 AA;  154988 MW;  C45293B2C5540562 CRC64;
     MKVSDRRKFE KANFDEFESA LNNKNDLVHC PSITLFESIP TEVRSFYEDE KSGLIKVVKF
     RTGAMDRKRS FEKIVVSVMV GKNVQKFLTF VEDEPDFQGG PIPSKYLIPK KINLMVYTLF
     QVHTLKFNRK DYDTLSLFYL NRGYYNELSF RVLERCHEIA SARPNDSSTM RTFTDFVSGA
     PIVRSLQKST IRRYGYNLAP HMFLLLHVDE LSIFSAYQAS LPGEKKVDTE RLKRDLCPRK
     PIEIKYFSQI CNDMMNKKDR LGDVLATAQR IRRRYNKNGS SEPRLKTLDG LTSERWIQWL
     GLESDYHCSF SSTRNAEDVV AGEAASSDHD QKISRVTRKR PREPKSTNDI LVAGQKLFGS
     SFEFRDLHQL RLCHEIYMAD TPSVAVQAPP GYGKTELFHL PLIALASKGD VKYVSFLFVP
     YTVLLANCMI RLGRCGCLNV APVRNFIEEG CDGVTDLYVG IYDDLASTNF TDRIAAWENI
     VECTFRTNNV KLGYLIVDEF HNFETEVYRQ SQFGGITNLD FDAFEKAIFL SGTAPEAVAD
     AALQRIGLTG LAKKSMDINE LKRSEDLSRG LSSYPTRMFN LIKEKSEVPL GHVHKIWKKV
     ESQPEEALKL LLALFEIEPE SKAIVVASTT NEVEELACSW RKYFRVVWIH GKLGAAEKVS
     RTKEFVTDGS MRVLIGTKLV TEGIDIKQLM MVIMLDNRLN IIELIQGVGR LRDGGLCYLL
     SRKNSWAARN RKGELPPIKE GCITEQVREF YGLESKKGKK GQHVGCCGSR TDLSADTVEL
     IERMDRLAEK QATASMSIVA LPSSFQESNS SDRCRKYCSS DEDSNTCIHG SANASTNATT
     NSSTNATTTA STNVRTSATT TASINVRTSA TTTESTNSST NATTTASTNV RTSATTTASI
     NVRTSATTTE STNSNTSATT TESTDSNTSA TTTESTDSST NATTTASINV RTSATTTEST
     NSNTNATTTE STNSSTNATT TEGTNSNTSA TTTASTNSST NATTTESTNA SAKEDANKDG
     NAEDNRFHPV TDINKESYKR KGSQMVLLER KKLKAQFPNT SENMNVLQFL GFRSDEIKHL
     FLYGIDVYFC PEGVFTQYGL CKGCQKMFEL CVCWAGQKVS YRRMAWEALA VERMLRNDEE
     YKEYLEDIEP YHGDPVGYLK FFSVKRGEIY SQIQRNYAWY LAITRRRETI SVLDSTRGKQ
     GSQVFRMSGR QIKELYYKVW SNLRESKTEV LQYFLNWDEK KCREEWEAKD DTVFVEALEK
     VGVFQRLRSM TSAGLQGPQY VKLQFSRHHR QLRSRYELSL GMHLRDQLAL GVTPSKVPHW
     TAFLSMLIGL FYNKTFRQKL EYLLEQISEV WLLPHWVDLA NVEVLAADNT RVPC
 
 
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