YL152_YEAST
ID YL152_YEAST Reviewed; 576 AA.
AC P54072; D6VYE7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Uncharacterized transporter YLR152C;
GN OrderedLocusNames=YLR152C; ORFNames=L9634.9;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the auxin efflux carrier (TC 2.A.69) family.
CC {ECO:0000305}.
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DR EMBL; Z73324; CAA97724.1; -; Genomic_DNA.
DR EMBL; U53879; AAB82386.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09463.1; -; Genomic_DNA.
DR PIR; S65001; S65001.
DR RefSeq; NP_013253.1; NM_001182039.1.
DR AlphaFoldDB; P54072; -.
DR BioGRID; 31421; 82.
DR DIP; DIP-6543N; -.
DR IntAct; P54072; 2.
DR MINT; P54072; -.
DR STRING; 4932.YLR152C; -.
DR TCDB; 2.A.69.2.6; the auxin efflux carrier (aec) family.
DR iPTMnet; P54072; -.
DR PaxDb; P54072; -.
DR PRIDE; P54072; -.
DR EnsemblFungi; YLR152C_mRNA; YLR152C; YLR152C.
DR GeneID; 850845; -.
DR KEGG; sce:YLR152C; -.
DR SGD; S000004142; YLR152C.
DR VEuPathDB; FungiDB:YLR152C; -.
DR eggNOG; ENOG502QU6H; Eukaryota.
DR GeneTree; ENSGT00940000176363; -.
DR HOGENOM; CLU_021924_0_1_1; -.
DR InParanoid; P54072; -.
DR OMA; GVAYCCI; -.
DR BioCyc; YEAST:G3O-32287-MON; -.
DR PRO; PR:P54072; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; P54072; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR InterPro; IPR040254; Ecm3-like.
DR InterPro; IPR004776; Mem_trans.
DR PANTHER; PTHR31274; PTHR31274; 1.
DR Pfam; PF03547; Mem_trans; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..576
FT /note="Uncharacterized transporter YLR152C"
FT /id="PRO_0000123806"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..45
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..400
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 422..437
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 459..476
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..497
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 498..512
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 534..545
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 567..576
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 576 AA; 64032 MW; 12319CA4985EC784 CRC64;
MSLSLGAAIY IALKPIFKIY TIMLVGYLVA KFDIVSMENA KGISNMVVNA ILPCLTFNKI
VSNISWRDIK EIGVIILSAF ILFVLGATGA LFTTFATTVP KKFFWGLIFA GFFPNISDLP
IAYIQSMGNG SIFTAEEADK GVAYSCIFLF IQSFLMMNFG MWRVVGLDFR DTKEPDSENI
TPSVSPAIDD RKLTEITKLP NITRPTNAYQ SEDARSNSDL SCNSITTNEM TPQAFYEGFT
GYIKPYKESN GASHKFESDL PHAEIYRVSS TYSSPGALEF SRIDGSSLSY SRISKNSDGR
SYRRKRKADM NELISKYSAA EKIRQGELDL SRPLSLTEEV GSRNASIGNV HTGYTDESSI
EEENCTNMAT DGRGSLSFFI ERHNLKWLQY FIINCLRPAS LGAILGIICA LIPWVKACFV
TTYVHVHKAP DGEPVLNFLM DFTEYIGNAC VPLGLLLLGG TLARLEIKSL PPGFIKSALL
MTCFRLIVIP IIGVLWVNKL YSIDWLDTGI GKFDMILTWS MPSATAQVYF TAFYTPACGD
HIQMNCLSVL FVMQYAILFI TVAFVVTYTL KVDLKV
