YL326_YEAST
ID YL326_YEAST Reviewed; 240 AA.
AC Q06170; D6VYW8;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Uncharacterized membrane protein YLR326W;
GN OrderedLocusNames=YLR326W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [4]
RP INDUCTION.
RX PubMed=16278933; DOI=10.1002/yea.1302;
RA de Lichtenberg U., Wernersson R., Jensen T.S., Nielsen H.B., Fausboell A.,
RA Schmidt P., Hansen F.B., Knudsen S., Brunak S.;
RT "New weakly expressed cell cycle-regulated genes in yeast.";
RL Yeast 22:1191-1201(2005).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- INDUCTION: During S phase of the cell cycle.
CC {ECO:0000269|PubMed:16278933}.
CC -!- MISCELLANEOUS: Present with 1520 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U20618; AAB64523.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09634.1; -; Genomic_DNA.
DR PIR; S53403; S53403.
DR RefSeq; NP_013430.1; NM_001182215.1.
DR AlphaFoldDB; Q06170; -.
DR BioGRID; 31589; 27.
DR DIP; DIP-3995N; -.
DR IntAct; Q06170; 12.
DR MINT; Q06170; -.
DR STRING; 4932.YLR326W; -.
DR iPTMnet; Q06170; -.
DR SwissPalm; Q06170; -.
DR PaxDb; Q06170; -.
DR PRIDE; Q06170; -.
DR EnsemblFungi; YLR326W_mRNA; YLR326W; YLR326W.
DR GeneID; 851036; -.
DR KEGG; sce:YLR326W; -.
DR SGD; S000004318; YLR326W.
DR VEuPathDB; FungiDB:YLR326W; -.
DR eggNOG; ENOG502RXX6; Eukaryota.
DR HOGENOM; CLU_084558_1_0_1; -.
DR InParanoid; Q06170; -.
DR OMA; TRDPFYE; -.
DR BioCyc; YEAST:G3O-32409-MON; -.
DR PRO; PR:Q06170; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q06170; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR025187; DUF4112.
DR PANTHER; PTHR35519; PTHR35519; 1.
DR Pfam; PF13430; DUF4112; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..240
FT /note="Uncharacterized membrane protein YLR326W"
FT /id="PRO_0000247210"
FT TOPO_DOM 1..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..131
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 181..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 240 AA; 27424 MW; 724CD7833AA9B416 CRC64;
MSGFIKSTLL GLGQDYLEDQ YQEFAEQHFQ PTRDPFYETN KDGKKHRRRL PYYCTKDESK
AWKKVQNKAW LHDKSLCGCC CWTNTIGWAP LLALLPVIGP LLMYWVHDKL IELADDRYKL
PAEIKVKMHG NIVIDLLISL VPILGSVFAW LHACSTRNAA IVYNFVGKRA LERKQAELMH
QKEENEKHSN ANTAPPVVGG NKNVNGNRNN SKMYNRPPVT APPAPAYTRS TNGRPQRGYR
