ID   YL377_MIMIV             Reviewed;        1147 AA.
AC   Q5UQW0;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Putative ATP-dependent RNA helicase L377;
DE            EC=3.6.4.13;
GN   OrderedLocusNames=MIMI_L377;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=16971431; DOI=10.1128/jvi.00940-06;
RA   Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H.,
RA   Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.;
RT   "Mimivirus giant particles incorporate a large fraction of anonymous and
RT   unique gene products.";
RL   J. Virol. 80:11678-11685(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:16971431}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY653733; AAV50646.1; -; Genomic_DNA.
DR   PRIDE; Q5UQW0; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW   Virion.
FT   CHAIN           1..1147
FT                   /note="Putative ATP-dependent RNA helicase L377"
FT                   /id="PRO_0000253411"
FT   DOMAIN          108..315
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   MOTIF           264..267
FT                   /note="DEAH box"
FT   BINDING         121..128
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   1147 AA;  133977 MW;  60DD5132F76A005A CRC64;
     MKIMEDQINP INIRKQKDLD DNLEEITSEN SEIAPADIEK KMLENHAYPS PTQEDFQRAI
     YVKRDFYIHS IPERKVLNTY DEIKEFRDNK CAGNFKLTES QTLLSNFINP NTPYRGLLMF
     WGTGVGKSCG AIAIAEKFKH MVEKYGTKIH VLVPGPINKQ NFLNEIIKCT GETYTKMFQD
     KTIVINEAEK NRIRKNALNV VNQYYRIMSY RSFYKKVLGE KIRDKVVTGN KVKLTSRKTE
     TGEFERDISI DRIYSLDNTL LIVDEAHNIT GNGEGDAVKK IIDVSKNLKV VFLSATPMKN
     LADSIVELIN YLRPKNYQME RDKIFTSQRG SEMDFKPGGR DYLRKMVRGY VSYLRGADPL
     TFAERVDIGE IPPGLDFTKV TRCFMLPFQL GVYDNVIATQ DDSLDRNSEA VANFVFPGLS
     KDRNSKNIEG YYGIKGMNEI RNQILNNSET LNRRIASTIL SEYEIEDPSN LMYLTDNNSV
     ISGNIFNEKY LKHFSIKFYS ALQKINETVY GKRNSGLIFI YLNLVRVGIS IFQEVLLMNG
     YLEYQENTNN YNLKRDTRCY FCDHKYGDHY NLPDDIPKHD FYPATFITVT GKSEEDIEQI
     PEEKHRILNN VFNNVNNREG KYLKIVIGSR VMNEGITLRN IKEIYILDVH FNLGKVDQAI
     GRGIRFCTHY GITNEKDPFP KVEVNKYVVS VKNGLSTEEQ LYKKAESKYK LIKQVERILQ
     EEAIDCPLNR NGNIFPEEMK RYANCGTKDN PCPAICGYMP CEFKCGDKLL NAKYYDPDRA
     VYKKITKSEL DYSTYNNALA SDEIDYSKAK IKEMYKLDFI YTLKDILRYV KKSYPVEKRE
     MFDDFYVYQA LNDLIPITGN DFNNFHDTIA DKYNRPGYLI YINTYYIFQP FDENENIPMY
     YRRIFTPPTI NKINVKDYIK NTPEYRQHKN LYQLDEEGPI DREYDFDSVQ DYYDSRDEFD
     YVGIIDRESS KRKNGTNSSG DEFKIRRKRP KILSKKRETG IPSFLGAVCS TSKDKKYLAS
     IMKKLNLDEN KSDSRMDICD RIKNKLFDLE KYSTNNMTYL IIPSNHPHIP FPLNLKDRVQ
     YIIDQIKRET RSSINPEIKT IKTTGEFNDI DYIYYELYYD SSMDKYQDIL TLYGAKKINN
     DWIIIIK