YL407_YEAST
ID YL407_YEAST Reviewed; 228 AA.
AC Q06070; D6VZ41;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Uncharacterized protein YLR407W;
GN OrderedLocusNames=YLR407W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 226-228.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP POSSIBLE FUNCTION.
RX PubMed=12702675; DOI=10.1093/genetics/163.4.1287;
RA Anderson J.B., Sirjusingh C., Parsons A.B., Boone C., Wickens C.,
RA Cowen L.E., Kohn L.M.;
RT "Mode of selection and experimental evolution of antifungal drug resistance
RT in Saccharomyces cerevisiae.";
RL Genetics 163:1287-1298(2003).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Deletion results in antifungal drug fluconazole-resistant
CC phenotype.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 3140 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U19729; AAB82340.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09707.2; -; Genomic_DNA.
DR PIR; S55963; S55963.
DR RefSeq; NP_013511.4; NM_001182295.4.
DR AlphaFoldDB; Q06070; -.
DR SMR; Q06070; -.
DR BioGRID; 31664; 96.
DR IntAct; Q06070; 2.
DR MINT; Q06070; -.
DR STRING; 4932.YLR407W; -.
DR iPTMnet; Q06070; -.
DR MaxQB; Q06070; -.
DR PaxDb; Q06070; -.
DR PRIDE; Q06070; -.
DR EnsemblFungi; YLR407W_mRNA; YLR407W; YLR407W.
DR GeneID; 851123; -.
DR KEGG; sce:YLR407W; -.
DR SGD; S000004399; YLR407W.
DR VEuPathDB; FungiDB:YLR407W; -.
DR eggNOG; ENOG502S6I5; Eukaryota.
DR HOGENOM; CLU_092540_0_0_1; -.
DR InParanoid; Q06070; -.
DR OMA; TETRKWA; -.
DR BioCyc; YEAST:G3O-32469-MON; -.
DR PRO; PR:Q06070; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q06070; protein.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR InterPro; IPR025124; DUF4050.
DR Pfam; PF13259; DUF4050; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..228
FT /note="Uncharacterized protein YLR407W"
FT /id="PRO_0000268628"
FT REGION 90..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 226..228
FT /note="GMP -> ACHD (in Ref. 1; AAB82340)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 228 AA; 25546 MW; 933C6FAF99264DA8 CRC64;
MTVSTSKTPK KNIKYTLTHT LQKWKETLKK ITHETLSSID DSSGSDEKIE ALFTVSQPAV
VASKGIDRDS GASMSQVGGG VNSTLEMKLT DESEESSSAN NTTTTASHTL SNSKKSTQNF
ENYNVVEERI KLAQKSKAPF CNAEKIWKRR RQLWTQPTEQ SESANNDGVT RREIFQAIPQ
EYYARVYKKL VVDDKPLREP LNLEDALQVI NAGWTETRKW ANAAKGMP
