YL456_YEAST
ID YL456_YEAST Reviewed; 204 AA.
AC Q06199; D6VZ90;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Pyridoxamine 5'-phosphate oxidase YLR456W homolog;
DE AltName: Full=PNP/PMP oxidase YLR456W homolog;
DE Short=PNPOx YLR456W homolog;
GN OrderedLocusNames=YLR456W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC Note=Binds 1 FMN per subunit. {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250}.
CC -!- MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the pyridoxamine 5'-phosphate oxidase family.
CC {ECO:0000305}.
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DR EMBL; U22383; AAB64720.1; -; Genomic_DNA.
DR EMBL; AY558231; AAS56557.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09756.1; -; Genomic_DNA.
DR PIR; S59415; S59415.
DR RefSeq; NP_013561.1; NM_001182344.1.
DR AlphaFoldDB; Q06199; -.
DR BioGRID; 31715; 54.
DR DIP; DIP-942N; -.
DR IntAct; Q06199; 1.
DR STRING; 4932.YLR456W; -.
DR MaxQB; Q06199; -.
DR PaxDb; Q06199; -.
DR PRIDE; Q06199; -.
DR EnsemblFungi; YLR456W_mRNA; YLR456W; YLR456W.
DR GeneID; 851178; -.
DR KEGG; sce:YLR456W; -.
DR SGD; S000004448; YLR456W.
DR VEuPathDB; FungiDB:YLR456W; -.
DR eggNOG; ENOG502S4PT; Eukaryota.
DR GeneTree; ENSGT00940000176627; -.
DR HOGENOM; CLU_078856_1_0_1; -.
DR OMA; HDWISAN; -.
DR BioCyc; YEAST:G3O-32509-MON; -.
DR PRO; PR:Q06199; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q06199; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.30.110.10; -; 1.
DR InterPro; IPR011576; Pyridox_Oxase_put.
DR InterPro; IPR012349; Split_barrel_FMN-bd.
DR Pfam; PF01243; Putative_PNPOx; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Flavoprotein; FMN; Nucleus; Reference proteome.
FT CHAIN 1..204
FT /note="Pyridoxamine 5'-phosphate oxidase YLR456W homolog"
FT /id="PRO_0000268191"
FT BINDING 65..66
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0000250"
FT BINDING 127
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0000250"
SQ SEQUENCE 204 AA; 23293 MW; F8936E876451850B CRC64;
MKLNEQIPKD LLRLIKSSKY VHVATCSSNC IPSVSLMHYI FVSSAETFHK HEYSIEIDCN
DYIIFTVFEK SVTFRNVMSN PNVALLFHDW ITAKNLTLRK KSVHSKDDFS FVESESTKFN
NFLRDLNQSE LNQVSATING IADIVNPNSE ESTYYRRLLL TVNPDADIFI LGEDTAIIKV
NIQKIKVSDM ENNTSTYGQT VQPV
