ID   YL498_MIMIV             Reviewed;         422 AA.
AC   Q5UQG2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Probable zinc-type alcohol dehydrogenase-like protein L498;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MIMI_L498;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=16971431; DOI=10.1128/jvi.00940-06;
RA   Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H.,
RA   Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.;
RT   "Mimivirus giant particles incorporate a large fraction of anonymous and
RT   unique gene products.";
RL   J. Virol. 80:11678-11685(2006).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Virion
CC       {ECO:0000269|PubMed:16971431}.
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DR   EMBL; AY653733; AAV50763.1; -; Genomic_DNA.
DR   RefSeq; YP_003987010.1; NC_014649.1.
DR   SMR; Q5UQG2; -.
DR   PRIDE; Q5UQG2; -.
DR   GeneID; 9925129; -.
DR   KEGG; vg:9925129; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Metal-binding; Oxidoreductase; Reference proteome; Virion;
KW   Zinc.
FT   CHAIN           1..422
FT                   /note="Probable zinc-type alcohol dehydrogenase-like
FT                   protein L498"
FT                   /id="PRO_0000160898"
FT   BINDING         108
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         129
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         160
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         163
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         166
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         174
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         231
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   422 AA;  47285 MW;  CB6953CDCFDAD6C6 CRC64;
     MSLEEKLNKY SNKLSMTNNL NKIDVYNKKI NKYKERQIYS NLKKPQPIDE SVISLYSLKN
     EYQKSPDKMT ALGFGVTDVG KPVELLVFDR KKPTNNEVSI EIYYTGICHS DWHFIVGEWK
     ADFPLIPGHE LIGRVIDIGP NVDKYSIGDI VCVSPVIDSC GHCKMCTHHI EQHCMNGATE
     IYNQKTRLPG DIKPSGPITY GGYSNIVIIK QHFVYKFPKN LDIERCAPLM CAGATTYSPL
     RQAKVGPGMK VGIVGIGGLG HIAVKIAKAM GAHVVAITRT EWKFKDSVNN LGANESILST
     NVWQMNQHKG SFDFILSTIP MAHDIVPYIE LLKYKATICT VGELFPTVIN GMDLAQHPCF
     LQSSLIAGSD EIKEMLAFCS EHNIMPDVQI IKADKINDTR QKLLESKAKY RYVIDIRASL
     NK