YL54_CAEEL
ID YL54_CAEEL Reviewed; 1283 AA.
AC P34434; Q8TA82;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Uncharacterized protein F44E2.4;
GN ORFNames=F44E2.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=12754521; DOI=10.1038/nbt829;
RA Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,
RA Kasai K., Takahashi N., Isobe T.;
RT "Lectin affinity capture, isotope-coded tagging and mass spectrometry to
RT identify N-linked glycoproteins.";
RL Nat. Biotechnol. 21:667-672(2003).
RN [4]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; FO081383; CCD71222.1; -; Genomic_DNA.
DR PIR; S44821; S44821.
DR RefSeq; NP_498952.1; NM_066551.5.
DR AlphaFoldDB; P34434; -.
DR SMR; P34434; -.
DR BioGRID; 41445; 1.
DR STRING; 6239.F44E2.4; -.
DR iPTMnet; P34434; -.
DR EPD; P34434; -.
DR PaxDb; P34434; -.
DR PeptideAtlas; P34434; -.
DR PRIDE; P34434; -.
DR EnsemblMetazoa; F44E2.4.1; F44E2.4.1; WBGene00018418.
DR GeneID; 176243; -.
DR KEGG; cel:CELE_F44E2.4; -.
DR UCSC; F44E2.4; c. elegans.
DR CTD; 176243; -.
DR WormBase; F44E2.4; CE28232; WBGene00018418; -.
DR eggNOG; KOG3593; Eukaryota.
DR HOGENOM; CLU_006565_0_0_1; -.
DR InParanoid; P34434; -.
DR OMA; IGLAPIC; -.
DR OrthoDB; 79459at2759; -.
DR PRO; PR:P34434; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00018418; Expressed in embryo and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; -; 1.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF57424; SSF57424; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1283
FT /note="Uncharacterized protein F44E2.4"
FT /id="PRO_0000065345"
FT TRANSMEM 1263..1283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 10..46
FT /note="LDL-receptor class A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT REGION 27..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 332..389
FT /evidence="ECO:0000255"
FT COMPBIAS 248..262
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..646
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754521,
FT ECO:0000269|PubMed:17761667"
FT DISULFID 11..23
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 18..36
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1283 AA; 139635 MW; D056EFB49E68A178 CRC64;
MATSAVQSAA CPPNTFTCAD GSCIPSDWKG DGEKDCEDGS DEEAVTGETT TKFDEVVSAP
TTPGSDEDCD WGMQQRIDNC SEPIVHFLSQ IERLNLKNMS FLTSSEIQSR FEAGCNLMTT
YQECVGNQKG CMPDEGVHSW GEVEVFMCQL VLPSVKEHAG CFKSSADPRC DASKTSSSST
LCGLVTSIQT ATSCLETIRP ETCSSDAIEM LSPIREETEH IVSAIRCVTP EQHASSTTLI
VDETTESTSA SAEDDDDDVL TTNTSEESTA TTAHDEEVEN KPALNINMAD AVNSLYYIYD
ICSANYSADP FAAIADKICA KQDEIAKWSN CYQKTLEKEK CAIRNATSKC EALISYNNNL
DCAIVTMNDE CEVDAQNLVV ELQEEVNDLI IAGKCFEDKK EEEKEPVNDG DFHLQSTLPK
CTEEQENGAL GCLVELVEIN KKLTAFANLN FLLEIASPNS TVVEGICSLF ARYEQCLSAT
VFKNSQRCSF ASPLNSLARI GLAPICSLDS RPLLSKHRDC FEKLATEADE DTNCQSSLST
LSNTVQMMLQ GVHGEALLCK SFYTIRDTFT CGERAVKNKC EADALTDLLS LKTKMTSLGE
EEGCPRDPPA NLDEIISRPV ARPTPVTMPP RAPTAKPLPI PSAPTPPVAS SKCSIEDQKK
FEECVKPLTS FQPHPLSVIA IPRDIDQACE AFHTFKACSA ESNCHPLWAR GMSAMFEYAC
NEANEQFKKV RKCIRETSMI EEVRSCVSDF SRGAPTAACM SSNRLHSCAI PQIQGKCGQD
AADWVSNYII RFANAIDVRC KVGRQLPVGR VVGIGCSAEE ESIIEHCAAP LNDIGSRVEE
LFAGGMQSLI KNINSLAPVF AGACNLTDEF KTCAHFLLEG RTSCVVSSCM VEAGRGICQL
SDPAKAIDDN LSCLFGQAQE PKFAQCIRST ISTLKQFNLS TLRAVLPKFI DCTRDIVVAK
CGESPIKIMK AMSTPDICPI RPHQAPIVPI NQPARVTPTL ETVLSSSTMV STSSESDSES
APEQETEPTV PSTTETTESP STPTDGCGES GLVEYLQCET HLDQFAFRPI SIIGDASKWD
QFCQMANQTY IPCVEGLKCK YEPAASAQIG LIDSICNRKI TLKDQKQHGM CLSEYTKSDA
GVACISDFGK IDQLDSSSPA QMCDGINQVM RCSTSEIEKR CGFDAVLHVF SIHMHWANLF
NASCILESPE PTKDSTSIDV NEVEPSRDQK PVVVTKDETT PVSITTAMNN DITESETTQS
PPVQSSVSFH IILAALIPFF ALF
