ID   CBIZ_HALSA              Reviewed;         231 AA.
AC   Q9HPK9;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Adenosylcobinamide amidohydrolase;
DE            Short=AdoCbi hydrolase;
DE            EC=3.5.1.90;
GN   Name=cbiZ; OrderedLocusNames=VNG_1583C;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   FUNCTION.
RX   PubMed=14990804; DOI=10.1073/pnas.0305939101;
RA   Woodson J.D., Escalante-Semerena J.C.;
RT   "CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12
RT   precursor cobinamide in archaea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:3591-3596(2004).
CC   -!- FUNCTION: Converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid
CC       (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic
CC       route. {ECO:0000269|PubMed:14990804}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosylcob(III)inamide + H2O = (R)-1-aminopropan-2-ol +
CC         adenosylcob(III)yrate; Xref=Rhea:RHEA:23504, ChEBI:CHEBI:2480,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:42677, ChEBI:CHEBI:58504; EC=3.5.1.90;
CC   -!- PATHWAY: Cofactor biosynthesis; dicyanocobinamide salvage pathway.
CC   -!- SIMILARITY: Belongs to the CbiZ family. {ECO:0000305}.
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DR   EMBL; AE004437; AAG19858.1; -; Genomic_DNA.
DR   PIR; F84311; F84311.
DR   RefSeq; WP_010903156.1; NC_002607.1.
DR   AlphaFoldDB; Q9HPK9; -.
DR   STRING; 64091.VNG_1583C; -.
DR   PaxDb; Q9HPK9; -.
DR   DNASU; 1448158; -.
DR   EnsemblBacteria; AAG19858; AAG19858; VNG_1583C.
DR   GeneID; 5953651; -.
DR   KEGG; hal:VNG_1583C; -.
DR   PATRIC; fig|64091.14.peg.1211; -.
DR   HOGENOM; CLU_087823_0_0_2; -.
DR   InParanoid; Q9HPK9; -.
DR   OMA; WRPGTVN; -.
DR   OrthoDB; 72101at2157; -.
DR   BRENDA; 3.5.1.90; 2559.
DR   UniPathway; UPA00297; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0043756; F:adenosylcobinamide hydrolase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR002808; AdoCbi_amidolase.
DR   Pfam; PF01955; CbiZ; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..231
FT                   /note="Adenosylcobinamide amidohydrolase"
FT                   /id="PRO_0000220406"
FT   REGION          200..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   231 AA;  23242 MW;  AC91E26DCF675DA6 CRC64;
     MFETTLHDGV LELAAPGARW LSTGWNGGDT RADRAYSITV PDDWAPDSTH EYVTDRLAAA
     GFAPRDDAPV LLTGVAQEHA RIARCGPVAV AATAGLSNPA ALPMDPDGGT LPDAKRAPPG
     TVNLVAATTR ALDDAALSNL VAVAAEAKAA TLLATAGFPG TTSDAVVVAC DPGGETAPYS
     GSATPVGAAT RACVREAVRA SLDSRDAASP DSVESAAHGT TTDVQAAVFR P