ID   CBK_TRIVA               Reviewed;         314 AA.
AC   O96432;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Carbamate kinase;
DE            EC=2.7.2.2;
GN   Name=CBK;
OS   Trichomonas vaginalis.
OC   Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC   Trichomonas.
OX   NCBI_TaxID=5722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   CHARACTERIZATION.
RC   STRAIN=WAA38;
RX   PubMed=10864518; DOI=10.1006/expr.2000.4507;
RA   Minotto L., Edwards M.R., Bagnara A.S.;
RT   "Trichomonas vaginalis: characterization, expression, and phylogenetic
RT   analysis of a carbamate kinase gene sequence.";
RL   Exp. Parasitol. 95:54-62(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate +
CC         H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2;
CC   -!- PATHWAY: Metabolic intermediate metabolism; carbamoyl phosphate
CC       degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the carbamate kinase family. {ECO:0000305}.
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DR   EMBL; AF050082; AAD02507.1; -; Genomic_DNA.
DR   AlphaFoldDB; O96432; -.
DR   SMR; O96432; -.
DR   STRING; 5722.XP_001328170.1; -.
DR   PRIDE; O96432; -.
DR   VEuPathDB; TrichDB:TVAG_261970; -.
DR   eggNOG; ENOG502S00U; Eukaryota.
DR   BRENDA; 2.7.2.2; 6459.
DR   UniPathway; UPA00996; UER00366.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008804; F:carbamate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0035975; P:carbamoyl phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04235; AAK_CK; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR003964; Carb_kinase.
DR   PANTHER; PTHR30409; PTHR30409; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PIRSF; PIRSF000723; Carbamate_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00746; arcC; 1.
PE   1: Evidence at protein level;
KW   Arginine metabolism; ATP-binding; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN           1..314
FT                   /note="Carbamate kinase"
FT                   /id="PRO_0000185153"
SQ   SEQUENCE   314 AA;  33927 MW;  4E00507941CF340C CRC64;
     MRIVVALGGN ALLQRGMKGT FQDQQAACRL AMSQIVKIVK DGNELVMTHG NGPQCGAIFL
     QNVAGEQEKV PAMPLHVCGA ETQGFLGELL QQELDGALRA EGIKKNVVSI VTQSFVDPKD
     PAFQNPTKPI GPFYSKEEAE FLRNERGYNM VEDAGRGYRM IVPSPVPQKF VEKEAIKTLV
     NSGFIVVCSG GGGIPVILDE QENRIEGVDA VIDKDLGASV LAAATNADAF MILTDVPEAL
     LNYRKENETA IRQATVAEME KYIEEGHFIK GSMLPKVQAC LRFVKSTGKP ALITALDCAL
     QALKGERGTK IVPN