YL8J_SCHPO
ID YL8J_SCHPO Reviewed; 522 AA.
AC Q9UTA1; Q9HFF3;
DT 23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Zinc finger protein C25B8.19c;
GN ORFNames=SPAC25B8.19c, SPAC683.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; CU329670; CAB61785.1; -; Genomic_DNA.
DR PIR; T50206; T50206.
DR RefSeq; NP_594479.2; NM_001019908.2.
DR AlphaFoldDB; Q9UTA1; -.
DR SMR; Q9UTA1; -.
DR BioGRID; 279188; 2.
DR STRING; 4896.SPAC25B8.19c.1; -.
DR iPTMnet; Q9UTA1; -.
DR MaxQB; Q9UTA1; -.
DR PaxDb; Q9UTA1; -.
DR EnsemblFungi; SPAC25B8.19c.1; SPAC25B8.19c.1:pep; SPAC25B8.19c.
DR GeneID; 2542738; -.
DR KEGG; spo:SPAC25B8.19c; -.
DR PomBase; SPAC25B8.19c; -.
DR VEuPathDB; FungiDB:SPAC25B8.19c; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_560383_0_0_1; -.
DR InParanoid; Q9UTA1; -.
DR OMA; TECLQGF; -.
DR PRO; PR:Q9UTA1; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IMP:PomBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 4: Predicted;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..522
FT /note="Zinc finger protein C25B8.19c"
FT /id="PRO_0000046867"
FT ZN_FING 468..495
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 496..522
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 55066 MW; D145254CE0666353 CRC64;
MSSDNTPSIN RRNNENPPQS SLPTTSGIVY NMFPACPYPH VQNPAFHGSV DVPQVAQKAF
DPQAATVSES ANVSRPTPAP VPPAGNTNTP TTSNSNQNLE NNVTSAASMP AILNAAGQLE
FSPSTNNALC CCTTVHGHPH MPPNLLAASS ARLRLPPIST ILGGTFADPT FLAAAAAAAV
PHYAHATTGS ATDASNTSNG NSNPAAVPAG FLSGYSPLSY AYFVAKANEL ALANQRQSSE
AAEQPSSKNN TSGANPPSSN NQEVTSAPIP AAPIVLPFQQ PFYPIVCPGC AQGALPQHIP
VPHNTEFAQY QPSSRDLQNH PTVDESRLSS VAPPASNTLN HANGNQAENA SESSTSQSND
SQGPANTSYP VSVPLPNDAE NNHTLSRNPY IPSLNFKDNM SAELSVVATL ASNSAQAHPM
GQQSDSNYSD HHNNDKRAHV SRRHSTSRKI AQSHTGSSST SSAANVRYRC TECLQGFSRP
SSLKIHTYSH TGERPFVCDY AGCGKAFNVR SNMRRHQRIH GL
