YLAT1_RAT
ID YLAT1_RAT Reviewed; 512 AA.
AC Q9R0S5; Q9QZ66;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Y+L amino acid transporter 1;
DE AltName: Full=Solute carrier family 7 member 7;
DE AltName: Full=y(+)L-type amino acid transporter 1;
DE Short=Y+LAT1;
DE Short=y+LAT-1;
GN Name=Slc7a7;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RA Kanai Y., Fukasawa Y., Segawa H., Endou H.;
RT "Characterization of a system y+L amino acid transporter.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RA Ng A.M.L., Yao S.Y.M., Cheeseman C.I., Young J.D.;
RT "cDNA encoding rat jejunal amino acid transporter y+LAT1.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=9878049; DOI=10.1093/emboj/18.1.49;
RA Pfeiffer R., Rossier G., Spindler B., Meier C., Kuehn L.C., Verrey F.;
RT "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members
RT of the glycoprotein-associated amino acid transporter family.";
RL EMBO J. 18:49-57(1999).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Involved in the sodium-independent uptake of dibasic amino
CC acids and sodium-dependent uptake of some neutral amino acids. Requires
CC coexpression with SLC3A2/4F2hc to mediate the uptake of arginine,
CC leucine and glutamine. Plays a role in nitric oxide synthesis via
CC transport of L-arginine, and is involved in the transport of L-arginine
CC in monocytes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Disulfide-linked heterodimer with the amino acid transport
CC protein SLC3A2/4F2hc. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in kidney cortex and intestine.
CC {ECO:0000269|PubMed:9878049}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000305}.
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DR EMBL; AB020520; BAA87325.1; -; mRNA.
DR EMBL; AF200684; AAF07216.1; -; mRNA.
DR EMBL; BC091142; AAH91142.1; -; mRNA.
DR RefSeq; NP_112631.1; NM_031341.1.
DR RefSeq; XP_006252082.1; XM_006252020.3.
DR RefSeq; XP_006252083.1; XM_006252021.3.
DR RefSeq; XP_006252085.1; XM_006252023.3.
DR RefSeq; XP_006252086.1; XM_006252024.3.
DR RefSeq; XP_008768927.1; XM_008770705.2.
DR RefSeq; XP_017455296.1; XM_017599807.1.
DR RefSeq; XP_017455297.1; XM_017599808.1.
DR RefSeq; XP_017455298.1; XM_017599809.1.
DR AlphaFoldDB; Q9R0S5; -.
DR SMR; Q9R0S5; -.
DR STRING; 10116.ENSRNOP00000014391; -.
DR TCDB; 2.A.3.8.7; the amino acid-polyamine-organocation (apc) family.
DR GlyGen; Q9R0S5; 1 site.
DR iPTMnet; Q9R0S5; -.
DR PhosphoSitePlus; Q9R0S5; -.
DR PaxDb; Q9R0S5; -.
DR Ensembl; ENSRNOT00000014391; ENSRNOP00000014391; ENSRNOG00000010296.
DR GeneID; 83509; -.
DR KEGG; rno:83509; -.
DR UCSC; RGD:619902; rat.
DR CTD; 9056; -.
DR RGD; 619902; Slc7a7.
DR eggNOG; KOG1287; Eukaryota.
DR GeneTree; ENSGT00940000160134; -.
DR HOGENOM; CLU_007946_3_0_1; -.
DR InParanoid; Q9R0S5; -.
DR OMA; VLAYYSF; -.
DR OrthoDB; 867824at2759; -.
DR PhylomeDB; Q9R0S5; -.
DR TreeFam; TF313355; -.
DR Reactome; R-RNO-210991; Basigin interactions.
DR Reactome; R-RNO-352230; Amino acid transport across the plasma membrane.
DR PRO; PR:Q9R0S5; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000010296; Expressed in adult mammalian kidney and 18 other tissues.
DR Genevisible; Q9R0S5; RN.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015174; F:basic amino acid transmembrane transporter activity; ISO:RGD.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0000821; P:regulation of arginine metabolic process; ISO:RGD.
DR InterPro; IPR002293; AA/rel_permease1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Cell membrane; Disulfide bond; Glycoprotein;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..512
FT /note="Y+L amino acid transporter 1"
FT /id="PRO_0000304936"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT CARBOHYD 328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 3
FT /note="A -> N (in Ref. 2; AAF07216)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 512 AA; 55641 MW; 708905B2ACB0A824 CRC64;
MVASTKYEVA AQNEADEADG SAQGDGAGPA AEQVKLKKEI SLLNGVCLIV GNMIGSGIFV
SPKGVLMYSA SFGLSLVIWA VGGIFSVFGA LCYAELGTTI KKSGASYAYI LEAFGGFLAF
IRLWTSLLII EPTSQAVIAI TFANYMVQPL FPSCGAPYAA GRLLAAACIC LLTFINCAYV
KWGTLVQDIF TYAKVLALIA VIIAGIVRLG QGATTNFEDS FEGSSFAMGD IALALYSALF
SYSGWDTLNY VTEEIRNPER NLPLSIGISM PIVTIIYLLT NVAYYSVLDI KDILASDAVA
VTFADQIFGI FNWTIPLAVA LSCFGGLNAS IVAASRLLFV GSREGHLPDA ICMIHVERFT
PVPSLLFNGI LALVYLCVED IFQLINYYSF SYWFFVGLSI VGQLYLRWKE PDRPRPLKLS
LFFPIVFCLC TIFLVAVPLY SDTINSLIGI GIALSGLPFY FLIIRVPEHK RPLCLRRIVA
STTRYLQIIC MSVAAEMDLE DGELPKQGPK SK
