YLAT2_DANRE
ID YLAT2_DANRE Reviewed; 468 AA.
AC Q59I64;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Y+L amino acid transporter 2;
DE AltName: Full=Solute carrier family 7 member 6;
DE Short=zfSlc7a6;
DE AltName: Full=y(+)L-type amino acid transporter 2;
DE Short=Y+LAT2;
DE Short=y+LAT-2;
GN Name=slc7a6 {ECO:0000312|ZFIN:ZDB-GENE-000607-21};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:BAD91397.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15753045; DOI=10.1016/j.cub.2005.02.018;
RA Kawakami A., Nojima Y., Toyoda A., Takahoko M., Satoh M., Tanaka H.,
RA Wada H., Masai I., Terasaki H., Sakaki Y., Takeda H., Okamoto H.;
RT "The zebrafish-secreted matrix protein You/Scube2 is implicated in long-
RT range regulation of hedgehog signaling.";
RL Curr. Biol. 15:480-488(2005).
CC -!- FUNCTION: Involved in the sodium-independent uptake of dibasic amino
CC acids and sodium-dependent uptake of some neutral amino acids.
CC {ECO:0000250|UniProtKB:Q92536}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000250|UniProtKB:Q92536}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q92536}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000255}.
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DR EMBL; AB193556; BAD91397.1; -; mRNA.
DR RefSeq; NP_001018310.1; NM_001020474.1.
DR AlphaFoldDB; Q59I64; -.
DR SMR; Q59I64; -.
DR STRING; 7955.ENSDARP00000124849; -.
DR PaxDb; Q59I64; -.
DR GeneID; 57957; -.
DR KEGG; dre:57957; -.
DR CTD; 9057; -.
DR ZFIN; ZDB-GENE-000607-21; slc7a6.
DR eggNOG; KOG1287; Eukaryota.
DR InParanoid; Q59I64; -.
DR PhylomeDB; Q59I64; -.
DR Reactome; R-DRE-210991; Basigin interactions.
DR Reactome; R-DRE-352230; Amino acid transport across the plasma membrane.
DR PRO; PR:Q59I64; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR InterPro; IPR002293; AA/rel_permease1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..468
FT /note="Y+L amino acid transporter 2"
FT /id="PRO_0000341479"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..129
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..161
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..385
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 407..413
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 435..468
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 468 AA; 51234 MW; 6DB58864D6F698FB CRC64;
MQLKKEISLL NGVSLIVGNM IGSGIFVSPK GVLIYSASYG LSLVIWAIGG IFSVVGALCY
AELGTTITKS GASYAYILES FGGFIAFIRL WTSLLIIEPT SQAVIAITFA NYLVQPLFPT
CEPPYSASRL IAAACICLLT FINSAYVKWG TRVQDVFTYA KVLALIVIII TGIVKLCQGF
TINFEDSFQG SSRDPGGIAL ALYSALFSYS GWDTLNFVTE EIKNPERNLP LSIAISMPIV
TIIYILTNVA YYAVLDMSAI LASDAVAVTF ADHTLGVMSW TIPIAVALSC YGGLNSSIIA
ASRLFFVGAR EGHLPDALSM IHIERFTPVP ALLFNCAMAL IYLTVEDVFQ LINYYSFSYW
FFVGLSIAGQ IYLRWKEPDR PRPLKLSLVY PIIFCLCVVF LVAVPLYSDT LNTLIGIAIA
LSGVPVYFLG IHLPESKRPP IITKLLSAIT RFTQFTCFYV LTEMDTVD
