YLAT2_XENLA
ID YLAT2_XENLA Reviewed; 510 AA.
AC A1L3M3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Y+L amino acid transporter 2;
DE AltName: Full=Solute carrier family 7 member 6;
DE AltName: Full=y(+)L-type amino acid transporter 2;
DE Short=Y+LAT2;
DE Short=y+LAT-2;
GN Name=slc7a6 {ECO:0000250|UniProtKB:Q92536};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000312|EMBL:AAI30195.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte {ECO:0000312|EMBL:AAI30195.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the sodium-independent uptake of dibasic amino
CC acids and sodium-dependent uptake of some neutral amino acids.
CC {ECO:0000250|UniProtKB:Q92536}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000250|UniProtKB:Q92536}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q92536}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000255}.
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DR EMBL; BC130194; AAI30195.1; -; mRNA.
DR RefSeq; NP_001091245.1; NM_001097776.1.
DR AlphaFoldDB; A1L3M3; -.
DR SMR; A1L3M3; -.
DR DNASU; 100037044; -.
DR GeneID; 100037044; -.
DR KEGG; xla:100037044; -.
DR CTD; 100037044; -.
DR Xenbase; XB-GENE-963220; slc7a6.L.
DR Proteomes; UP000186698; Chromosome 4L.
DR Bgee; 100037044; Expressed in zone of skin and 19 other tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR002293; AA/rel_permease1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..510
FT /note="Y+L amino acid transporter 2"
FT /id="PRO_0000341480"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..64
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..162
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..188
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..230
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..305
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 380
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..418
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 440..446
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 468..510
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 56001 MW; C962E98708F09C62 CRC64;
MKETENQTVP LNSTSPEDTS NTSNMASEGT HETMQLKKEI SLLNGVSLIV GNMIGSGIFV
SPKGVLIYSA SYGLSLILWA LGGIFSVIGA PCYAELGTTI KKSGASYAYI LEAFGGFVAF
IRLWTSLLII EPTSQAVIAI TFANYLVQPV FPSCNPPYMA SRLIAAACVC LITFINCAYV
KWGTRVQDLF TYAKVIALIA IIITGIVKLS QGQTENFEDS FAGSSWDAGD ISLGLYSALF
SYSGWDTLNF VTEEIKNPER NLPLSIGISM PLVTIIYILT NVAYYTVLDF NAVVASEAVA
VTFADLVYGV FSWTIPVAVA LSCFGGLNSS ILAASRLFFV GAREGHLPDM LCLIHRERFT
PVPALLFNCA ATLVYLAVKD VFQLINYYSF SYWFFVGLSI AGQIYLRYKR PELPRPVKLS
LFYPIVFCLC TVFLVIVPLY SDTVNSLIGI GIALSGIPVY FMGIYLPESK RPPFISKILA
FLTRWTQMIF SCVLTEMDPN DEKKEEAKSN
