YLAT2_XENTR
ID YLAT2_XENTR Reviewed; 514 AA.
AC Q28I80;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Y+L amino acid transporter 2;
DE AltName: Full=Solute carrier family 7 member 6;
DE AltName: Full=y(+)L-type amino acid transporter 2;
DE Short=Y+LAT2;
DE Short=y+LAT-2;
GN Name=slc7a6 {ECO:0000250|UniProtKB:Q92536}; ORFNames=TEgg023f12.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ81262.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg {ECO:0000312|EMBL:CAJ81262.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the sodium-independent uptake of dibasic amino
CC acids and sodium-dependent uptake of some neutral amino acids.
CC {ECO:0000250|UniProtKB:Q92536}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000250|UniProtKB:Q92536}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q92536}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000255}.
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DR EMBL; CR760541; CAJ81262.1; -; mRNA.
DR RefSeq; NP_001017197.1; NM_001017197.2.
DR RefSeq; XP_012816638.1; XM_012961184.2.
DR AlphaFoldDB; Q28I80; -.
DR SMR; Q28I80; -.
DR STRING; 8364.ENSXETP00000014625; -.
DR PaxDb; Q28I80; -.
DR Ensembl; ENSXETT00000014625; ENSXETP00000014625; ENSXETG00000006680.
DR GeneID; 549951; -.
DR KEGG; xtr:549951; -.
DR CTD; 9057; -.
DR Xenbase; XB-GENE-963214; slc7a6.
DR eggNOG; KOG1287; Eukaryota.
DR HOGENOM; CLU_007946_3_0_1; -.
DR InParanoid; Q28I80; -.
DR OMA; ITFINCA; -.
DR OrthoDB; 621852at2759; -.
DR PhylomeDB; Q28I80; -.
DR TreeFam; TF313355; -.
DR Reactome; R-XTR-352230; Amino acid transport across the plasma membrane.
DR Proteomes; UP000008143; Chromosome 4.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000006680; Expressed in testis and 11 other tissues.
DR ExpressionAtlas; Q28I80; baseline.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR InterPro; IPR002293; AA/rel_permease1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..514
FT /note="Y+L amino acid transporter 2"
FT /id="PRO_0000341481"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..73
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..162
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..188
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..230
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 380
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..418
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 440..446
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 468..514
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 56654 MW; CA0FEC508BA6FCEF CRC64;
MKETENQTVP LNSTSPGDTS HTSTSDSKDP QDTMQLKKEI SLLNGVSLIV GNMIGSGIFV
SPKGVLIYSA SYGLSLILWS LGGIFSVIGA LCYAELGTTI KKSGASYAYI LEAFGDFVAF
IRLWTSLLII EPTSQAVIAI TFANYLVQPV FPSCYPPYMA SRLIAAACVC LITFINCAYV
KWGTRVQDLF TYAKVIALIA IIITGIVKLS QGQTENFEDS FAGSSWDAGE ISLGLYSALF
SYSGWDTLNF VTEEIKNPER NLPLSIGISM PLVTIIYILT NVAYYTVLDF NAVVASEAVA
VTFADMVYGV FSWTIPVAVA LSCFGGLNSS ILAASRLFFV GAREGHLPDM LCLIHQERFT
PVPALLFNCV ATLIYLAVKD VFQLINYYSF SYWFFVGLSI AGQIYLRIKK PELPRPVKLS
LFYPIVFCLC TVFLVIVPLY SDTVNSLIGI GIALSGIPVY FMGIYLPESK RPPFISRVLA
FLTRRTQMIF NCVLTEMDPI DEKKQNQTEN RKVQ
