YLBF_BACSU
ID YLBF_BACSU Reviewed; 149 AA.
AC O34412;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Regulatory protein YlbF;
GN Name=ylbF; OrderedLocusNames=BSU14990;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Bertero M., Presecan E., Glaser P., Richou A., Danchin A.;
RT "Bacillus subtilis chromosomal region downstream nprE.";
RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP INVOLVEMENT IN COMPETENCE, AND INVOLVEMENT IN SPORULATION.
RC STRAIN=168;
RX PubMed=10712692; DOI=10.1046/j.1365-2958.2000.01779.x;
RA Tortosa P., Albano M., Dubnau D.;
RT "Characterization of ylbF, a new gene involved in competence development
RT and sporulation in Bacillus subtilis.";
RL Mol. Microbiol. 35:1110-1119(2000).
RN [4]
RP ROLE IN FORMATION OF BIOFILMS.
RC STRAIN=168, and 3610;
RX PubMed=15175311; DOI=10.1128/jb.186.12.3970-3979.2004;
RA Branda S.S., Gonzalez-Pastor J.E., Dervyn E., Ehrlich S.D., Losick R.,
RA Kolter R.;
RT "Genes involved in formation of structured multicellular communities by
RT Bacillus subtilis.";
RL J. Bacteriol. 186:3970-3979(2004).
CC -!- FUNCTION: Regulates sporulation prior to stage II. Positively controls
CC the competence regulator ComK at a post-transcriptional level. May
CC modulate the translation, stability or activity of ComS. May work
CC together with YmcA to regulate community development.
CC {ECO:0000269|PubMed:15175311}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR EMBL; Z98682; CAB11352.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13372.1; -; Genomic_DNA.
DR PIR; C69874; C69874.
DR RefSeq; NP_389382.1; NC_000964.3.
DR RefSeq; WP_003221370.1; NZ_JNCM01000035.1.
DR PDB; 6PRK; X-ray; 3.20 A; A=1-121.
DR PDBsum; 6PRK; -.
DR AlphaFoldDB; O34412; -.
DR SMR; O34412; -.
DR STRING; 224308.BSU14990; -.
DR PaxDb; O34412; -.
DR EnsemblBacteria; CAB13372; CAB13372; BSU_14990.
DR GeneID; 64303390; -.
DR GeneID; 939945; -.
DR KEGG; bsu:BSU14990; -.
DR PATRIC; fig|224308.179.peg.1634; -.
DR eggNOG; COG3679; Bacteria.
DR OMA; PYQNIKE; -.
DR PhylomeDB; O34412; -.
DR BioCyc; BSUB:BSU14990-MON; -.
DR PRO; PR:O34412; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1500.10; -; 1.
DR InterPro; IPR010368; Com_YlbF.
DR InterPro; IPR023378; YheA/YmcA-like_dom_sf.
DR Pfam; PF06133; Com_YlbF; 1.
DR SUPFAM; SSF158622; SSF158622; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Competence; Cytoplasm; Reference proteome; Sporulation.
FT CHAIN 1..149
FT /note="Regulatory protein YlbF"
FT /id="PRO_0000066288"
FT HELIX 8..22
FT /evidence="ECO:0007829|PDB:6PRK"
FT HELIX 25..39
FT /evidence="ECO:0007829|PDB:6PRK"
FT HELIX 42..63
FT /evidence="ECO:0007829|PDB:6PRK"
FT HELIX 70..86
FT /evidence="ECO:0007829|PDB:6PRK"
FT HELIX 88..116
FT /evidence="ECO:0007829|PDB:6PRK"
SQ SEQUENCE 149 AA; 16914 MW; F9E273EC4A7800EF CRC64;
MYATMESVRL QSEAQQLAEM ILQSETAENY RNCYKRLQED EEAGRIIRSF IKIKEQYEDV
QRFGKYHPDY REISRKMREI KRELDLNDKV ADFKRAENEL QSILDEVSVE IGTAVSEHVK
VPTGNPYFDG LSSCGGGCGS GGSCGCKVS
