ID   YLJ2_CAEEL              Reviewed;        2236 AA.
AC   P34367; Q18736;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2013, sequence version 4.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Uncharacterized protein C50C3.2;
GN   ORFNames=C50C3.2/C50C3.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the spectrin family. {ECO:0000305}.
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DR   EMBL; FO080718; CCD66129.2; -; Genomic_DNA.
DR   PIR; S44621; S44621.
DR   RefSeq; NP_498787.3; NM_066386.4.
DR   AlphaFoldDB; P34367; -.
DR   SMR; P34367; -.
DR   BioGRID; 41359; 2.
DR   IntAct; P34367; 2.
DR   MINT; P34367; -.
DR   STRING; 6239.C50C3.2; -.
DR   EPD; P34367; -.
DR   PaxDb; P34367; -.
DR   PeptideAtlas; P34367; -.
DR   EnsemblMetazoa; C50C3.2.1; C50C3.2.1; WBGene00016800.
DR   GeneID; 176154; -.
DR   KEGG; cel:CELE_C50C3.2; -.
DR   CTD; 176154; -.
DR   WormBase; C50C3.2; CE47978; WBGene00016800; -.
DR   eggNOG; KOG0040; Eukaryota.
DR   GeneTree; ENSGT00970000196675; -.
DR   HOGENOM; CLU_230646_0_0_1; -.
DR   InParanoid; P34367; -.
DR   OMA; MNEVEKM; -.
DR   OrthoDB; 63395at2759; -.
DR   PRO; PR:P34367; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00016800; Expressed in material anatomical entity and 2 other tissues.
DR   GO; GO:0030054; C:cell junction; IBA:GO_Central.
DR   GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR   GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0048666; P:neuron development; IBA:GO_Central.
DR   CDD; cd00176; SPEC; 3.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   Pfam; PF00435; Spectrin; 2.
DR   SMART; SM00150; SPEC; 7.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   3: Inferred from homology;
KW   Calcium; Coiled coil; Metal-binding; Reference proteome; Repeat.
FT   CHAIN           1..2236
FT                   /note="Uncharacterized protein C50C3.2"
FT                   /id="PRO_0000073458"
FT   REPEAT          46..146
FT                   /note="Spectrin 1"
FT   REPEAT          238..335
FT                   /note="Spectrin 2"
FT   REPEAT          839..949
FT                   /note="Spectrin 3"
FT   REPEAT          1048..1146
FT                   /note="Spectrin 4"
FT   REPEAT          1261..1361
FT                   /note="Spectrin 5"
FT   REPEAT          1367..1459
FT                   /note="Spectrin 6"
FT   REPEAT          1562..1667
FT                   /note="Spectrin 7"
FT   DOMAIN          2104..2139
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          2141..2176
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   COILED          496..541
FT                   /evidence="ECO:0000255"
FT   COILED          603..631
FT                   /evidence="ECO:0000255"
FT   COILED          1835..1869
FT                   /evidence="ECO:0000255"
FT   BINDING         2154
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         2156
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         2158
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         2160
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         2165
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ   SEQUENCE   2236 AA;  260999 MW;  F619B18EA2AB2A6C CRC64;
     MKAIIHDDTV VREIEGQRVQ VLQKFADFEL KAINKRSSII QSRQLQVYLR SAAEFKQVIE
     SLIESSEAVV TSQCSESSIR GQKVIGRLQQ EADGKHNNLP MLENEAARLL KEGHYASDEI
     QKTFNNVLSR WEYLLKLLAL KWRQLEKEIE SIEFKNKCDS IVDWILKIKE SDESGKEIFD
     EIRKCSMVWN EISATFQQML DPTATDTSNY EKVHETWSNF QEYIDSLHKK LSENERFQKF
     VDNAEDLIKW MDDKEKEICE KYSKMDFEVM MKYRKTVEIE MKSVEQRIKD LKEQFVGMEN
     DNLRNIPDPK NHVIDVEQRF ESFQAFVQKW KTDIENSADA DKLMKEAENI CCWSSEKIED
     LKIMATSDTP DCDEIIMWIE TNNFDFNSWD NVVVQFLASS QELLNKQNNG NVKQEVERTT
     ELYELAKRTM KTCNEFLEDR IQTINMEKLI FQTHQKAVIL ASFLQNHEES PEDMNAEDIE
     KEIRVIDGIT VRCTSVVEQI ENIEDELRQK PEQLNQLSVY ASKQVNDLNE MKEVLKTTVN
     SRKAILQRLL DVTYFLDNCC ETRKHTDTML SNVKSSRVKL EIVQPIKDQL DSLKVEMVDM
     MLDDQQKNMA NEELRKTYEN LKKIEMEVGR QASQKEARKA ADRTEAFVGR VQNWIDNNQI
     QDDTDIVSET VNLRRTTTHY QHLLSICASY KKSIDSKLEE LANVYTDNDP RCLLEGIQNS
     VENFEVKIHQ KVDDTKKLLH ITENMNELNS QNEWIRAKIK SLSAEPLWDS LLIAQKMRRR
     HDNDFEEIAN RRKQITEVIQ KSATTKDQPI LLEIEQNWDR MKDLFDERGG VLERIIKLYE
     YDEESSTTSE WLREKMICAD TIEPKEDESF NEVMVKKLEA LTEEVENYKP RIVETHALLE
     DALVTPNTKD STSQQTMKLK AVLARKQGEI ESDYKALKKL VERKLKTLKA ILQDADISHQ
     IADIEQWIEV EQNQLNRYLA SDSDELPTKL DDVMTNIQRR RSNLTDIKCN VVGQVQMQKI
     DDAFGMLDVF SFEVHRIRQK ACRLEIFKKL ESQTEDVIDA IQMKLEEINV SQSTSRKRQV
     AGDDLSNLAG DLETLRRRVV EALDRSKEVR AANADLAPQV YDTEERLEKQ WTDVSKAYEN
     HKKRMERCKI LSELDNEMIN MEQWIDTFNE EVTVVIGSIH DGLGVQVGLE SIDTWREELS
     HRVDQLGGVK NSLSSVGNAI TEQDKMDPWL ERVSNIENNL VKARETIDTK QDDLCRFADI
     LGAERDCERL YSWASGKRHQ LETEATMCDA KTLVRRMNEV EKMMMSRIGE VDQLRDFLDN
     LKASKTSDTF QTTELENKFE LLDVEWNHLE EELRRREVDL NDSMSQILID EQFDTIRQWI
     KERTEALEAD VEVSNKTKPD DIERMQKRHD ELASDINDYH TIYEDFLNNG QVEEEKVQVI
     RHLWSSLIES STTRQKSLAQ ECQKSRLFEL LDGMSIWLID AETDVHSTTN FIGLYNSVDA
     EKASRLLVSL GEQAGEKDDI LIRIQCDESV DVIVEKLRNG ISQLQMLIKA NNEDLDVWKS
     MQKVVTAIDD EICWFKEINV IFSSTNVGND VSSNDVLKRK HQRLQLETQR REQKVAKVVY
     LTTELVSSHR RPSLEYKFVE IDEKVAELTE LLESNRQIAE IRTNRLEKWT EYFVTMNEIR
     EKEQLLDQIL DLKTGLPETV LADVERKLQV LETVGDHMDT LTIKAEQMSD DEVIRTKVAV
     TAIDQLRKKW LKMNEELKKM HQKIKESIEF TKFVSTCDTG IQCIREQEEK IGNLVRHQKP
     ASNFENTAYH STMTFVETYT KDTFEKLKVV CRKLQNSTDA EKKLSLVSER LNALKKQLDL
     LAEKIAVDDK FKLKVQNIQD EYSRTACELG NWLEQAEEDV SDVVWFQTKD SSEDCRETLL
     EILGTLRNEK SDLLGELELL EVELAELKED VKTFTWHSFK TLATRMERLD QTISDRIRIA
     DGEISRHSDN EKICEQAACT LKTYHNVIVD VKKELEILYS LKLEDQKKSL INLIDKVQKR
     GMIQDLEKWR SLMESRYIFN NKFSSATPHG VLVEMCQCLE LMSSMLRSVE QSIADRNHNG
     VTEKQLHEFE LAFDYFDRER NGWLDYKHFE LCLKSQGYNF SAENTLKETM TLLDPSTTGH
     IQKHDYVRYM VKHETTNILD DHSAIEDALK NLDARKISDS MPRKEAEFFM SKIAKHAETS
     SDQVYLEYKD FVNSFY