YLL53_YEAST
ID YLL53_YEAST Reviewed; 152 AA.
AC P0CD98; D6VXV5; O93938; Q12258; Q12302; Q9C411;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Putative uncharacterized protein YLL053C;
GN OrderedLocusNames=YLL053C; ORFNames=L0587;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP POLYMORPHISM.
RX PubMed=10870101;
RX DOI=10.1002/1097-0061(200007)16:10<897::aid-yea583>3.0.co;2-t;
RA Laize V., Tacnet F., Ripoche P., Hohmann S.;
RT "Polymorphism of Saccharomyces cerevisiae aquaporins.";
RL Yeast 16:897-903(2000).
RN [4]
RP POLYMORPHISM.
RX PubMed=11158584; DOI=10.1073/pnas.98.3.1000;
RA Carbrey J.M., Bonhivers M., Boeke J.D., Agre P.;
RT "Aquaporins in Saccharomyces: characterization of a second functional water
RT channel protein.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:1000-1005(2001).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. This is the C-terminal
CC part of aquaporin-2. In strain S288c and many laboratory strains, a
CC natural 11 bp deletion in position 109 leads to a frameshift, which
CC disrupts the gene coding for this protein and produces two ORFs YLL052C
CC and YLL053C. A contiguous sequence for aquaporin-2 can be found in
CC strain Sigma 1278B (AC P0CD89). {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z73158; CAA97505.1; -; Genomic_DNA.
DR EMBL; Z47973; CAA88004.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09271.1; -; Genomic_DNA.
DR PIR; S50967; S50967.
DR RefSeq; NP_013047.1; NM_001181873.1.
DR AlphaFoldDB; P0CD98; -.
DR SMR; P0CD98; -.
DR BioGRID; 31262; 98.
DR STRING; 4932.YLL053C; -.
DR PaxDb; P0CD98; -.
DR PRIDE; P0CD98; -.
DR EnsemblFungi; YLL053C_mRNA; YLL053C; YLL053C.
DR GeneID; 850673; -.
DR KEGG; sce:YLL053C; -.
DR SGD; S000003976; YLL053C.
DR VEuPathDB; FungiDB:YLL053C; -.
DR eggNOG; KOG0223; Eukaryota.
DR GeneTree; ENSGT00940000176123; -.
DR HOGENOM; CLU_127260_0_0_1; -.
DR InParanoid; P0CD98; -.
DR OMA; HWIYWIS; -.
DR BioCyc; YEAST:G3O-32152-MON; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; P0CD98; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015250; F:water channel activity; IBA:GO_Central.
DR Gene3D; 1.20.1080.10; -; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR034294; Aquaporin_transptr.
DR InterPro; IPR000425; MIP.
DR PANTHER; PTHR19139; PTHR19139; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; SSF81338; 1.
PE 5: Uncertain;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..152
FT /note="Putative uncharacterized protein YLL053C"
FT /id="PRO_0000391656"
FT TOPO_DOM 1..5
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOTIF 92..94
FT /note="NPA"
SQ SEQUENCE 152 AA; 16456 MW; 5E36E11629D1EF23 CRC64;
MWFPQIIAGM AAGGAASAMT PGKVLFTNAL GLGCSRSRGL FLEMFGTAVL CLTVLMTAVE
KRETNFMAAL PIGISLFMAH MALTGYTGTG VNPARSLGAA VAARYFPHYH WIYWISPLLG
AFLAWSVWQL LQILDYTTYV NAEKAAGQKK ED
