ID   YLOH_SCHPO              Reviewed;         619 AA.
AC   Q9URY3; Q9UUJ2;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 4.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=TBC domain-containing protein C1952.17c;
GN   ORFNames=SPAC1952.17c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC       protein(s).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329670; CAB52581.2; -; Genomic_DNA.
DR   RefSeq; NP_594819.2; NM_001020248.2.
DR   AlphaFoldDB; Q9URY3; -.
DR   SMR; Q9URY3; -.
DR   BioGRID; 279008; 3.
DR   STRING; 4896.SPAC1952.17c.1; -.
DR   iPTMnet; Q9URY3; -.
DR   MaxQB; Q9URY3; -.
DR   PaxDb; Q9URY3; -.
DR   PRIDE; Q9URY3; -.
DR   EnsemblFungi; SPAC1952.17c.1; SPAC1952.17c.1:pep; SPAC1952.17c.
DR   GeneID; 2542551; -.
DR   KEGG; spo:SPAC1952.17c; -.
DR   PomBase; SPAC1952.17c; -.
DR   VEuPathDB; FungiDB:SPAC1952.17c; -.
DR   eggNOG; KOG4567; Eukaryota.
DR   HOGENOM; CLU_018687_0_1_1; -.
DR   InParanoid; Q9URY3; -.
DR   OMA; CFIELMQ; -.
DR   PhylomeDB; Q9URY3; -.
DR   PRO; PR:Q9URY3; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005096; F:GTPase activator activity; ISM:PomBase.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; ISS:PomBase.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   4: Predicted;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..619
FT                   /note="TBC domain-containing protein C1952.17c"
FT                   /id="PRO_0000352834"
FT   DOMAIN          34..387
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ   SEQUENCE   619 AA;  71879 MW;  06ECEBF7D984AB98 CRC64;
     MDYKQRIEKF KDILNSEEPI SLPGLCSLCI QGIPDEYSLR AKAWMLMLEF LPTDRSNWQS
     VLEKHRKTYT SFVQELLIDP WRKLTLHEES GENSDHPLNT SDDSKWKEYF DDNQILEQID
     KDIRRTLPDL SFFQGKSEIN KKPSVNNVSE NISVNTEDDK VEEVGQKLNY TKITSIDQSQ
     ETPVHLSTID FSKFQEECHL VLQGRIYRLE NESTSSSTTA LSTPRQSMDS KRTINAEAIA
     GENKLGLHRE AAERILFIYA KLNPGIGYVQ GMNEILAPLY YVLATDPTYE NYYLCECDAF
     FLFTQMMVQV RDLYEKTLDH DSDHGIHFLM SKFTERLKKY DYELWENLEE KQIHPTYYSF
     RWFTCLLSQE FPLPDVIRLW DSIIADQMKA RLFGKNDDGF NGAYDFLMDF CCSILIELRE
     SILERNFADS IKLLQAHFNV DMPKLLNLTF ELQHLRKTSK NDEDMSYVRK NSYNTNALAN
     SLKNRVLSTY NTVKANVPQS SSSYTDNNKQ KEPLEEKRSF FPSFRSSLDG VSPTQGRKSG
     EENIRTIFAK PTAHIGENGW SNLKVKGSSI FQRFGNFVGD TMRYITEEEE SSEEEDLTTS
     RRKIGITSKR KVSVKRNVI