YLW3_SCHPO
ID YLW3_SCHPO Reviewed; 453 AA.
AC Q9UT11;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Uncharacterized zinc transporter P8A3.03;
DE Flags: Precursor;
GN ORFNames=SPAP8A3.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC KE4/Catsup subfamily. {ECO:0000305}.
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DR EMBL; CU329670; CAB55170.1; -; Genomic_DNA.
DR PIR; T39240; T39240.
DR RefSeq; NP_594942.1; NM_001020373.2.
DR AlphaFoldDB; Q9UT11; -.
DR SMR; Q9UT11; -.
DR BioGRID; 278601; 15.
DR STRING; 4896.SPAP8A3.03.1; -.
DR SwissPalm; Q9UT11; -.
DR MaxQB; Q9UT11; -.
DR PaxDb; Q9UT11; -.
DR EnsemblFungi; SPAP8A3.03.1; SPAP8A3.03.1:pep; SPAP8A3.03.
DR GeneID; 2542125; -.
DR KEGG; spo:SPAP8A3.03; -.
DR PomBase; SPAP8A3.03; -.
DR VEuPathDB; FungiDB:SPAP8A3.03; -.
DR eggNOG; KOG2693; Eukaryota.
DR HOGENOM; CLU_015114_0_0_1; -.
DR InParanoid; Q9UT11; -.
DR OMA; IKGGHCH; -.
DR PhylomeDB; Q9UT11; -.
DR Reactome; R-SPO-442380; Zinc influx into cells by the SLC39 gene family.
DR PRO; PR:Q9UT11; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISO:PomBase.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISO:PomBase.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; ISO:PomBase.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..453
FT /note="Uncharacterized zinc transporter P8A3.03"
FT /id="PRO_0000316235"
FT TOPO_DOM 24..137
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..194
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 380..399
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 421..432
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 229..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 50278 MW; FDCEE025119895AF CRC64;
MFLLQRFFIY GLFLACFYTT VFGEKHFEAE EYRDSFLSQE NMNKINHTTI ERLFREMTEN
DPSLLSSSKT LAELSKGELA KAREDLKSVL SFLKNNLPVD TESSSEAFTI EKDNNSCVWL
NSVKSFVEKQ FSYSSGTNGI LATFLTAIPP NIFILLVPKS FDTSMLNLFV AVSAGSLLGD
VFLQLLPTVY STNGGDFPAS SVYSILIGAL VFFLMDKGIR ILIHERPSSL SKPKKDGEET
SSVNKPSASS TQTDVKGVEG LRKRNVKDDQ NSKGHEPDLI RHVVEEVSEE YNDKTVVYLN
LLCDSFHNFM DGLAITSAFF TNTSIGISTT FAVLLHEIPA EIGDLAILLR NGYTKSQVLV
LQMITMVTGL LGAIVATYIY TASSSSSPYG SFLLQLEDKL LPFTAGGFLY IAYLGVFPEL
LEINLSKGKL GNMIYTALYM MFIVGGFSFL YYV
