ID   YLX6_SCHPO              Reviewed;         258 AA.
AC   Q9URX0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Uncharacterized oxidoreductase C922.06;
DE            EC=1.-.-.-;
GN   ORFNames=SPAC922.06;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB63553.1; -; Genomic_DNA.
DR   PIR; T50271; T50271.
DR   RefSeq; NP_595006.1; NM_001020437.2.
DR   AlphaFoldDB; Q9URX0; -.
DR   SMR; Q9URX0; -.
DR   BioGRID; 279967; 2.
DR   STRING; 4896.SPAC922.06.1; -.
DR   PaxDb; Q9URX0; -.
DR   PRIDE; Q9URX0; -.
DR   EnsemblFungi; SPAC922.06.1; SPAC922.06.1:pep; SPAC922.06.
DR   GeneID; 2543550; -.
DR   KEGG; spo:SPAC922.06; -.
DR   PomBase; SPAC922.06; -.
DR   VEuPathDB; FungiDB:SPAC922.06; -.
DR   eggNOG; KOG0725; Eukaryota.
DR   HOGENOM; CLU_010194_1_2_1; -.
DR   InParanoid; Q9URX0; -.
DR   PhylomeDB; Q9URX0; -.
DR   Reactome; R-SPO-193144; Estrogen biosynthesis.
DR   Reactome; R-SPO-194002; Glucocorticoid biosynthesis.
DR   Reactome; R-SPO-5365859; RA biosynthesis pathway.
DR   Reactome; R-SPO-77108; Utilization of Ketone Bodies.
DR   Reactome; R-SPO-77111; Synthesis of Ketone Bodies.
DR   PRO; PR:Q9URX0; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0004316; F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; ISO:PomBase.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0009107; P:lipoate biosynthetic process; ISO:PomBase.
DR   GO; GO:0008202; P:steroid metabolic process; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Oxidoreductase; Reference proteome.
FT   CHAIN           1..258
FT                   /note="Uncharacterized oxidoreductase C922.06"
FT                   /id="PRO_0000374033"
FT   ACT_SITE        145
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         12..18
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         133
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   258 AA;  27750 MW;  F0A8A7A11D2F3ADD CRC64;
     MTVEGRVVLI TGAAGGIGKV LCKMFTELGD RVAGIDIVDP SKVQDAALAL QADVSKADQI
     ETAIEKVIQT LGPIDVLINN AGLADDTPFE QLSHESWDHD VSLVLRGNYL TQRYVIPHMA
     KQGKGGSIVN IGSVNGHIYL GSPAYSAAKA GLENLTKALA VRYGPLGIRV NVCAPGTIWS
     PAWDERFKKH PDVGDRMKRW YPVGRLGTPE DVARAVIFLA DSKNSFITGT TLYVDGGLLA
     GNPCLIQDIY SENNNFVF