YLX7_SCHPO
ID YLX7_SCHPO Reviewed; 496 AA.
AC Q9URW9;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Putative aldehyde dehydrogenase-like protein C922.07c;
DE EC=1.2.1.-;
GN ORFNames=SPAC922.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAB63554.1; -; Genomic_DNA.
DR PIR; T50272; T50272.
DR RefSeq; NP_595007.1; NM_001020438.2.
DR AlphaFoldDB; Q9URW9; -.
DR SMR; Q9URW9; -.
DR BioGRID; 280073; 7.
DR STRING; 4896.SPAC922.07c.1; -.
DR MaxQB; Q9URW9; -.
DR PaxDb; Q9URW9; -.
DR EnsemblFungi; SPAC922.07c.1; SPAC922.07c.1:pep; SPAC922.07c.
DR GeneID; 2543659; -.
DR KEGG; spo:SPAC922.07c; -.
DR PomBase; SPAC922.07c; -.
DR VEuPathDB; FungiDB:SPAC922.07c; -.
DR eggNOG; KOG2450; Eukaryota.
DR HOGENOM; CLU_005391_0_1_1; -.
DR InParanoid; Q9URW9; -.
DR OMA; NDDLGEV; -.
DR PhylomeDB; Q9URW9; -.
DR PRO; PR:Q9URW9; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; ISO:PomBase.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0019483; P:beta-alanine biosynthetic process; ISO:PomBase.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; IC:PomBase.
DR GO; GO:0006598; P:polyamine catabolic process; ISO:PomBase.
DR Gene3D; 3.40.309.10; -; 1.
DR Gene3D; 3.40.605.10; -; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; SSF53720; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; NAD; Nucleus; Oxidoreductase; Reference proteome.
FT CHAIN 1..496
FT /note="Putative aldehyde dehydrogenase-like protein
FT C922.07c"
FT /id="PRO_0000310349"
FT ACT_SITE 263
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT ACT_SITE 297
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT BINDING 241..246
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT SITE 165
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000250"
SQ SEQUENCE 496 AA; 54028 MW; 2F20A876EC975039 CRC64;
MSEDLFVSIN FPNGKSVKQP IGLYINGEWH KSAETWETVD PSIEEVIAKV YLAGEKEIDY
AVKSAKEAFK TWKKVPGSEK GELLMKLAEL TEKHADTLAA IEAMDSGKPL VSNARGDVDG
TIALLRYCAG WADKIYGQVI PTGPEKLAYA KRTPIGVCGQ IVPWNYPLNM AGWKIAPALA
AGNCIIIKSA ETTPLSLLYF ATLVEEAGFP KGVVNIISGL GTVAGSYMAK HPGIDKIAFT
GSTKVGVIVQ QLAASNLKAV TLECGGKSPF LVFEDADLDQ AVKWAALGIM YNSGQICTSN
SRIYVQDSVY DKFIELFKKH VIQDYIVGMP FDDNTVVGPV VNKTQYNRIK NYIEQGKKEG
AKLVLGDEPL PLKQGYFISP TIFADCSENM TIVKEEIFGP VVAISKFKTE DEAIEKANNT
TYGLAAMCFT KDLERAHRVS DELEAGMVFI NSTENSDIQA PFGGIKMSGI GNELGSNGIE
MYTQIKAVHI NFNNKL
