YLXH_HELPY
ID YLXH_HELPY Reviewed; 294 AA.
AC O25678;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Flagellum site-determining protein YlxH;
GN Name=ylxH; OrderedLocusNames=HP_1034;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=11A;
RX PubMed=15361076; DOI=10.1111/j.1083-4389.2004.00268.x;
RA van Amsterdam K., van der Ende A.;
RT "Helicobacter pylori HP1034 (ylxH) is required for motility.";
RL Helicobacter 9:387-395(2004).
CC -!- FUNCTION: Involved in the placement and assembly of flagella.
CC {ECO:0000269|PubMed:15361076}.
CC -!- DISRUPTION PHENOTYPE: Non-motile, has no flagella, and has reduced
CC expression of FlaA. {ECO:0000269|PubMed:15361076}.
CC -!- SIMILARITY: Belongs to the ParA family. {ECO:0000305}.
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DR EMBL; AE000511; AAD08077.1; -; Genomic_DNA.
DR PIR; B64649; B64649.
DR RefSeq; NP_207824.1; NC_000915.1.
DR RefSeq; WP_001064464.1; NC_018939.1.
DR AlphaFoldDB; O25678; -.
DR SMR; O25678; -.
DR DIP; DIP-3249N; -.
DR IntAct; O25678; 12.
DR MINT; O25678; -.
DR STRING; 85962.C694_05350; -.
DR PaxDb; O25678; -.
DR EnsemblBacteria; AAD08077; AAD08077; HP_1034.
DR KEGG; hpy:HP_1034; -.
DR PATRIC; fig|85962.47.peg.1113; -.
DR eggNOG; COG0455; Bacteria.
DR OMA; FKVAKNN; -.
DR PhylomeDB; O25678; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR GO; GO:0051782; P:negative regulation of cell division; IBA:GO_Central.
DR CDD; cd02038; FlhG-like; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR033875; FlhG.
DR InterPro; IPR025501; MinD_FleN.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR033756; YlxH/NBP35.
DR Pfam; PF10609; ParA; 1.
DR PIRSF; PIRSF003092; MinD; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; Bacterial flagellum biogenesis; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..294
FT /note="Flagellum site-determining protein YlxH"
FT /id="PRO_0000419250"
FT BINDING 35..42
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 294 AA; 32039 MW; 1A9F870C3FAC2C37 CRC64;
MNNQASRLDN LMNIKNPKSF FDNKGNTKFI AITSGKGGVG KSNISANLAY SLYKKGYKVG
VFDADIGLAN LDVIFGVKTH KNILHALKGE AKLQEIICEI EPGLCLIPGD SGEEILKYIS
GAEALDQFVD EEGVLSSLDY IVVDTGAGIG ATTQAFLNAS DCVVIVTTPD PSAITDAYAC
IKINSKNKDE LFLIANMVAQ PKEGRATYER LFKVAKNNIA SLELHYLGAI ENSSLLKRYV
RERKILRKIA PNDLFSQSID QIAGLLVSKL ETGALEIPKE GLKSFFKRLL KYLG
