ID   YM085_YEAST             Reviewed;         432 AA.
AC   P0CF18; D6VZQ8; Q3E7C0; Q6B308; Q6WV01;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Uncharacterized protein YMR085W;
GN   OrderedLocusNames=YMR085W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11, AND CONFIRMATION OF FRAMESHIFT.
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   PubMed=12844361; DOI=10.1186/gb-2003-4-7-r45;
RA   Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A.,
RA   Gates K., Gaffney T.D., Philippsen P.;
RT   "Reinvestigation of the Saccharomyces cerevisiae genome annotation by
RT   comparison to the genome of a related fungus: Ashbya gossypii.";
RL   Genome Biol. 4:R45.1-R45.13(2003).
CC   -!- CAUTION: Could be the product of a pseudogene. This is the C-terminal
CC       part of a putative glutamine--fructose-6-phosphate aminotransferase.
CC       Strain S288c has a frameshift in position 258, which disrupts the gene
CC       coding for this protein and produces two ORFs YMR084W and YMR085W. A
CC       contiguous sequence for this protein can be found in strain YJM789 (AC
CC       A6ZME2). {ECO:0000305}.
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DR   EMBL; Z49259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY268137; AAR26284.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA09982.1; -; Genomic_DNA.
DR   RefSeq; NP_013802.1; NM_001182584.1.
DR   AlphaFoldDB; P0CF18; -.
DR   SMR; P0CF18; -.
DR   BioGRID; 35260; 12.
DR   STRING; 4932.YMR085W; -.
DR   PaxDb; P0CF18; -.
DR   PRIDE; P0CF18; -.
DR   EnsemblFungi; YMR085W_mRNA; YMR085W; YMR085W.
DR   GeneID; 855109; -.
DR   KEGG; sce:YMR085W; -.
DR   SGD; S000004690; YMR085W.
DR   VEuPathDB; FungiDB:YMR085W; -.
DR   eggNOG; KOG1268; Eukaryota.
DR   GeneTree; ENSGT00940000173234; -.
DR   HOGENOM; CLU_012520_2_3_1; -.
DR   InParanoid; P0CF18; -.
DR   OMA; QSFYVMA; -.
DR   BioCyc; YEAST:G3O-32785-MON; -.
DR   Reactome; R-SCE-446210; Synthesis of UDP-N-acetyl-glucosamine.
DR   PRO; PR:P0CF18; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; P0CF18; protein.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IBA:GO_Central.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IBA:GO_Central.
DR   GO; GO:0034221; P:fungal-type cell wall chitin biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006487; P:protein N-linked glycosylation; IBA:GO_Central.
DR   GO; GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IBA:GO_Central.
DR   CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR   CDD; cd05009; SIS_GlmS_GlmD_2; 1.
DR   InterPro; IPR035466; GlmS/AgaS_SIS.
DR   InterPro; IPR035490; GlmS/FrlB_SIS.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   Pfam; PF01380; SIS; 2.
DR   SUPFAM; SSF53697; SSF53697; 1.
DR   PROSITE; PS51464; SIS; 2.
PE   5: Uncertain;
KW   Reference proteome; Repeat.
FT   CHAIN           1..432
FT                   /note="Uncharacterized protein YMR085W"
FT                   /id="PRO_0000393382"
FT   DOMAIN          105..244
FT                   /note="SIS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT   DOMAIN          277..422
FT                   /note="SIS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
SQ   SEQUENCE   432 AA;  48502 MW;  B2FCAC474794126C CRC64;
     MEFYLSSDCA SLARYVSKVV YLEDNDIAHI YDGELHIHCS KIGSEDFSFR TVQKLELELS
     KIKKGPYDNF MQKEIYEQCE TTKNVMRGRV DAFTNRVVLG GLENWLTELR RAKRIIMIAS
     KASFHSCLAA RPIFEELMEV PVNVELALDF VDRNCCIFRN DVCIFVSRSG ETTDTINALN
     YCIKKEAVTI GVVNCSGSSI SRFTHCGVHT NTGPEKGIAT TKSYTSQYIA LVMIALWMSE
     DLVSKIERRK EIIQALTIVP SQIKEVLELE PLIIELCDKK LKQHDTFLLL GRGYQFASAL
     EGASKMKEIS YVHSESILTN ELGHRVLAVA SDNPPIIAFA TKDAFSPKIA SCIDQIIERK
     GNPIIICNKG HKIWEQDKQK GNVVTLEVPQ TVDCLQGILN VIPLQLISYW LAIKKDIGVD
     LPRDSAMSAP DI