ID   YM67_CAEEL              Reviewed;         510 AA.
AC   P34528; Q95QC8;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Putative serine protease K12H4.7;
DE            EC=3.4.-.-;
DE   Flags: Precursor;
GN   ORFNames=K12H4.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=P34528-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=P34528-2; Sequence=VSP_005370;
CC   -!- SIMILARITY: Belongs to the peptidase S28 family. {ECO:0000305}.
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DR   EMBL; FO081380; CCD71198.1; -; Genomic_DNA.
DR   EMBL; FO081380; CCD71199.1; -; Genomic_DNA.
DR   PIR; S44851; S44851.
DR   RefSeq; NP_498758.2; NM_066357.4. [P34528-1]
DR   RefSeq; NP_498759.2; NM_066358.5.
DR   AlphaFoldDB; P34528; -.
DR   SMR; P34528; -.
DR   BioGRID; 41342; 12.
DR   IntAct; P34528; 2.
DR   STRING; 6239.K12H4.7a; -.
DR   ESTHER; caeel-ym67; Prolylcarboxypeptidase.
DR   MEROPS; S28.A11; -.
DR   EPD; P34528; -.
DR   PaxDb; P34528; -.
DR   PeptideAtlas; P34528; -.
DR   EnsemblMetazoa; K12H4.7.1; K12H4.7.1; WBGene00019682. [P34528-1]
DR   GeneID; 176136; -.
DR   KEGG; cel:CELE_K12H4.7; -.
DR   UCSC; K12H4.7a; c. elegans. [P34528-1]
DR   CTD; 176136; -.
DR   WormBase; K12H4.7a; CE32696; WBGene00019682; -. [P34528-1]
DR   WormBase; K12H4.7b; CE32697; WBGene00019682; -. [P34528-2]
DR   eggNOG; KOG2182; Eukaryota.
DR   GeneTree; ENSGT00940000159838; -.
DR   HOGENOM; CLU_020959_3_1_1; -.
DR   InParanoid; P34528; -.
DR   OMA; DVMLNTT; -.
DR   OrthoDB; 555765at2759; -.
DR   PhylomeDB; P34528; -.
DR   PRO; PR:P34528; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00019682; Expressed in larva and 4 other tissues.
DR   GO; GO:0008239; F:dipeptidyl-peptidase activity; IBA:GO_Central.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.980; -; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR008758; Peptidase_S28.
DR   InterPro; IPR042269; Ser_carbopepase_S28_SKS.
DR   Pfam; PF05577; Peptidase_S28; 1.
DR   SUPFAM; SSF53474; SSF53474; 2.
PE   3: Inferred from homology;
KW   Alternative splicing; Glycoprotein; Hydrolase; Protease;
KW   Reference proteome; Serine protease; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..510
FT                   /note="Putative serine protease K12H4.7"
FT                   /id="PRO_0000027322"
FT   ACT_SITE        187
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        452
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        477
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        234
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        473
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         365..401
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_005370"
SQ   SEQUENCE   510 AA;  56567 MW;  1BCDCFF2FCE6F50C CRC64;
     MKTLLAVLLA ACVLTQVLSA PSNEQRVRRN MIRGRPRGGM KKTPPMSSVS HMINFDNVVS
     STFTQTLDHF DSSVGKTFQQ RYYHNNQWYK AGGPAFLMLG GEGPESSYWV SYPGLEITNL
     AAKQGAWVFD IEHRFYGETH PTSDMSVPNL KYLSSAQAIE DAAAFIKAMT AKFPQLANAK
     WVTFGGSYSG ALAAWTRAKH PELVYAAVGS SGPVQAEVDF KEYLEVVQNS ITRNSTECAA
     SVTQGFNLVA SLLQTSDGRK QLKTAFHLCQ DIQMDDKSLK YFWETVYSPY MEVVQYSGDA
     AGSFATQLTI SHAICRYHIN TKSTPLQKLK QVNDYFNQVS GYFGCNDIDY NGFISFMKDE
     TFGEAQSDRA WVWQTCTEFG YYQSTSSATA GPWFGGVSNL PAQYYIDECT AIYGAAYNSQ
     EVQTSVDYTN QYYGGRDNLN TDRILLPNGD IDPWHALGKL TSSNSNIVPV VINGTAHCAD
     MYGASSLDSM YLTNARQRIS DVLDGWLHAN