YM8M_YEAST
ID YM8M_YEAST Reviewed; 540 AA.
AC Q03263; D6W0A6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Uncharacterized transporter YMR279C;
GN OrderedLocusNames=YMR279C; ORFNames=YM8021.05C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; Z49704; CAA89777.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA10180.1; -; Genomic_DNA.
DR PIR; S54586; S54586.
DR RefSeq; NP_014006.1; NM_001182786.1.
DR AlphaFoldDB; Q03263; -.
DR SMR; Q03263; -.
DR BioGRID; 35458; 58.
DR DIP; DIP-4642N; -.
DR IntAct; Q03263; 5.
DR MINT; Q03263; -.
DR STRING; 4932.YMR279C; -.
DR TCDB; 2.A.1.3.69; the major facilitator superfamily (mfs).
DR PaxDb; Q03263; -.
DR PRIDE; Q03263; -.
DR EnsemblFungi; YMR279C_mRNA; YMR279C; YMR279C.
DR GeneID; 855322; -.
DR KEGG; sce:YMR279C; -.
DR SGD; S000004892; YMR279C.
DR VEuPathDB; FungiDB:YMR279C; -.
DR eggNOG; KOG0254; Eukaryota.
DR GeneTree; ENSGT00940000176573; -.
DR HOGENOM; CLU_000960_27_4_1; -.
DR InParanoid; Q03263; -.
DR OMA; LEWRPIF; -.
DR BioCyc; YEAST:G3O-32950-MON; -.
DR PRO; PR:Q03263; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q03263; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0080139; F:borate efflux transmembrane transporter activity; ISA:SGD.
DR GO; GO:0035445; P:borate transmembrane transport; IMP:SGD.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..540
FT /note="Uncharacterized transporter YMR279C"
FT /id="PRO_0000173429"
FT TOPO_DOM 1..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..169
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..232
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..295
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..334
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 356..372
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..398
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..429
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..461
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 483..502
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 503..523
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 524..540
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 540 AA; 59562 MW; 687D06CB0D70AF91 CRC64;
MFSIFKKKTS VQGTDSEIDE KITVKAKDKV VVSTEDEEVT TIVSSTKSTQ VTNDSPWQDP
TYFSSFGKEL MFIATCMLAQ LLNQAGQTHA LCIMNVLSKS FNSEANNQAW LMASFPLAAG
SFILISGRLG DIYGLKKMLI VGYVIVIVWS IISGLSKYSN SDAFFITSRA FQGVGIAFIL
PNIMGLVGHV YKVGSFRKNI VISFIGACAP TGGMFGGLFG GLIVTEDPNQ WPWVFYAFGI
ATFLSLLMAW YSIPNNVPTN IHGLSMDWTG SALAIIGLIL FNFVWNQAPI VGWDKPYIIV
LLIISVIFLV AFFVYESKYA EVPLLPRAMT KNRHMIMILL AVFLGWGSFG IWTFYYVSFQ
LNLRHYSPVW TGGTYFVFVI FGSMAAFFVA FSIKRLGPAL LLCFSLMAFD AGSIMFSVLP
VEQSYWKLNF AMQAILCFGM DLSFPASSII LSDGLPMQYQ GMAGSLVNTV INYSASLCLG
MGGTVEHQIN KSGNDLLKGY RAAVYLGVGL ASLGVVISVT YMLENLWNRH RKSEDRSLEA
