ID   YMCR_STRLA              Reviewed;         281 AA.
AC   P43458;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator in mcrB 3'region;
OS   Streptomyces lavendulae.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B619;
RX   PubMed=7517396; DOI=10.1128/jb.176.14.4448-4454.1994;
RA   August P.R., Flickinger M.C., Sherman D.H.;
RT   "Cloning and analysis of a locus (mcr) involved in mitomycin C resistance
RT   in Streptomyces lavendulae.";
RL   J. Bacteriol. 176:4448-4454(1994).
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DR   EMBL; L29247; AAA21478.1; -; Genomic_DNA.
DR   PIR; C55519; C55519.
DR   AlphaFoldDB; P43458; -.
DR   SMR; P43458; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Antibiotic resistance; DNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..281
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   in mcrB 3'region"
FT                   /id="PRO_0000194634"
FT   DOMAIN          184..281
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        201..222
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        248..271
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   REGION          21..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  30090 MW;  295F14FA24FCC71C CRC64;
     MRPCGSVCQH RHFRHAACGT QPLPWRTTAP EPGAPPHEHL SARRKIHSVS PEYEERTSRL
     PGAIGWVQGA PGCTGGGETT TVLPDGCIDL LWTAGRLLVS GPDTSAYSTH RGFWVGVRFS
     PGIAPALLGI PAHELRDQRV DLADLWPGAG TRRLTERVDG GGRTRPPPSR IWHCGVAADA
     EPVDPLLRAV VVSLEAGRSV TATADSVGLG ARQLHRRSLA AFGYGPKTLA RVLRMQRALR
     LARAGVPFAE TATLAGFADQ AHLARDVREM AGSSLSELVE R