ID   YME1_SCHMA              Reviewed;         662 AA.
AC   P46508;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=ATP-dependent zinc metalloprotease YME1 homolog;
DE            EC=3.4.24.-;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Liberian;
RA   Menrath M.;
RL   Thesis (1994), Heinrich-Heine University / Duesseldorf, Germany.
CC   -!- FUNCTION: Putative ATP-dependent protease.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000305};
CC   -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC       family. {ECO:0000305}.
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DR   EMBL; Z29947; CAA82844.1; -; mRNA.
DR   PIR; S42826; S42826.
DR   AlphaFoldDB; P46508; -.
DR   SMR; P46508; -.
DR   MEROPS; M41.A11; -.
DR   eggNOG; KOG0734; Eukaryota.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.760; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR005936; FtsH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000642; Peptidase_M41.
DR   InterPro; IPR037219; Peptidase_M41-like.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   Pfam; PF01434; Peptidase_M41; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF140990; SSF140990; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01241; FtsH_fam; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Hydrolase; Metal-binding; Metalloprotease; Nucleotide-binding;
KW   Protease; Reference proteome; Zinc.
FT   CHAIN           1..662
FT                   /note="ATP-dependent zinc metalloprotease YME1 homolog"
FT                   /id="PRO_0000084666"
FT   ACT_SITE        426
FT                   /evidence="ECO:0000250"
FT   BINDING         206..213
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         425
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         429
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         503
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   662 AA;  72940 MW;  8D36F28A9ACBBB75 CRC64;
     MIVSPCCRII RTCCVSNRGT FHSRLAALYP SYIKIPNNHA RIFVTKSRKI NRPSSSFIID
     TKEARQRNSD SSTVSSDLDE ILKDQTPSAQ LRLVDAYRRG FQSSTDSGKS SNKMQMWRTI
     IIKTILFGVV SCFTIVFLKK TLVGTFPKFL DQNIGSFAEN TDVSFSDVQG CDEVKKELVD
     VVEFLRNPEK FNQIGAKLPK GVLLVGPPGV GKTLLAKAVS GEAQVPFLYA SGSSFDEVLV
     GLGASRIRQL FTTAKQNSPC LVFIDEIDSV GGNRTFSPHH PFANQTINQL LAEMDGFQSK
     EGIIVLGATN QAEVLDKALL RPGRFDVQIH VSPPTYEGRI ALLNLYLKKV KTGSNIDIEK
     LAHGTVGYTG ADIQNLVNQA AIAAALRNDP FVEMHHLWDA RDRLIMGPAK RRPLDDQTNR
     VSAFHEAGHA LVALLTADSI PLHKVTIIPR GEAGGLTSFL QEKDISFMTR AQLLAQLDVL
     MGGRVGEELV FGADKVTNGA ADDFRKATIL AQNMVKRFGF SSKIGPRVIP DTQDEQLGEA
     TRDLIDKEVD QLLNDSLTRV RTLLSSQSKQ HKLLAEALLH FETLTKDEVL AVLAGKMKPP
     KTQSVTSKST TLLPQLGPST STEIPRMIVS LIIVHVVDFI SFFCPFKDTL HTYTHTHKLL
     FS