ID   YME2_ASHGO              Reviewed;         806 AA.
AC   Q751P7;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; OrderedLocusNames=AGL358C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54133.1; -; Genomic_DNA.
DR   RefSeq; NP_986309.1; NM_211371.1.
DR   AlphaFoldDB; Q751P7; -.
DR   STRING; 33169.AAS54133; -.
DR   EnsemblFungi; AAS54133; AAS54133; AGOS_AGL358C.
DR   GeneID; 4622602; -.
DR   KEGG; ago:AGOS_AGL358C; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_007861_1_0_1; -.
DR   InParanoid; Q751P7; -.
DR   OMA; FQFFRPY; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..806
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343111"
FT   TOPO_DOM        26..268
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..806
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          181..253
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   806 AA;  91664 MW;  58A3E8BFE6D5A176 CRC64;
     MMFLEMQRAF MLHGRRAVTR SAVGVRYISE DIQQKDAQAG EKATATATGV IYKSDEETLM
     YFDNVYPRAT SLWRPTQWYN ILLSNQSREA VREKIMRLAS PASNPVHGLE LRSTIPIKRD
     GGVFATFRVP REYTRAQVNA LIQANTQQES SKSLLAAFTR AAAFPVKGVP WIEDLKRLPN
     NVVRVEVEGP ALSEEELYSL FRRYGTILDI YPAGKNGYAT IRYRSFRGAI CAKNCVSGIE
     INGSTLHVKF EPVVRAHAIR DFFVNHPRIA IPLLIALLSI CAVLIFDPIR EFSIEQKITR
     MYTLSRDNFV VKSILRLTSY TVSSVKHLWG YDDDQPEKRQ LWQERVEKVN DLKMWLEENN
     NTFVVVTGPR GSGKHELVMQ HTLHDRPNVL YLDCDTLIKS RTDSKFLRNA AHQIGYFPIF
     PWLNSVTTLV DLAVQGLTGQ KSGLSESKET QFRNMLNTAM MSIRHIALSG YKATLHSGDD
     VTTVKEEDYL QQHPERKPVI VIDRFSNKAE INGFVYKELA DWASMLVQMN IAHVIFLTES
     VSPNQLLAEA LPNQVFKFLF LSDASKDSAR SYVLSQLYPS SPAYSEKMPA ADADANEEYR
     KEIDRALEPI GGRMLDLQAF VRRVKSGEEP SEALEKMVEQ ASEQITQIFL SERSEPIKTA
     QAWELIELLS QNDVVKYGDI VFRPLFKSSP EAGLLELEKN GLITISRNRG VLQDIRPAKP
     LFKAAFSYLL QDKDLSIVLR TGYYLRLIAF ETGRIKKWEE ELRLLAKVSD QRICKSRLNY
     LASKIDASSG VINSCEDKVK EMSKRI