YME2_ASPNC
ID YME2_ASPNC Reviewed; 832 AA.
AC A2QPL8;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Mitochondrial escape protein 2;
DE Flags: Precursor;
GN Name=yme2; ORFNames=An07g09890;
OS Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC controlling the mtDNA escape. Involved in the regulation of mtDNA
CC nucleotide structure and number. May have a dispensable role in early
CC maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR EMBL; AM270154; CAK39755.1; -; Genomic_DNA.
DR RefSeq; XP_001392064.1; XM_001392027.1.
DR AlphaFoldDB; A2QPL8; -.
DR PaxDb; A2QPL8; -.
DR PRIDE; A2QPL8; -.
DR EnsemblFungi; CAK39755; CAK39755; An07g09890.
DR GeneID; 4982258; -.
DR KEGG; ang:ANI_1_2178064; -.
DR VEuPathDB; FungiDB:An07g09890; -.
DR HOGENOM; CLU_007861_1_0_1; -.
DR Proteomes; UP000006706; Chromosome 4L.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR CDD; cd12433; RRM_Yme2p_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR018850; Mt_escape_2_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR039627; Yme2_C.
DR InterPro; IPR034260; Yme2_RRM.
DR PANTHER; PTHR32198; PTHR32198; 1.
DR Pfam; PF10443; RNA12; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW mRNA processing; Reference proteome; RNA-binding; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..40
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 41..832
FT /note="Mitochondrial escape protein 2"
FT /id="PRO_0000343114"
FT TOPO_DOM 41..294
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..832
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT DOMAIN 187..279
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT COILED 766..831
FT /evidence="ECO:0000255"
SQ SEQUENCE 832 AA; 94310 MW; 554BCB2A6A8AED9C CRC64;
MMRIPYRAVV PRATLLHARF SRPPAVPSLT KAFIVSRRTS SHASFIETGH IDVKDDEGLV
FVNNIFPSKL QWLLQGPLSG NKTYEEALKR INRPHLAASD PLHIIRRVFP QSLNVDIREV
IPRFREGGAF VKYVRKDGVR DNDIVTAVQH HLEHNPIRPW FNPFQQVKVA HVHGRPWIED
LYRIPSQRLR VEFLPGSVDG AATELTTETL YSFFRRYGKL RDIERQPTDS KIAPRYAFVS
FTRQKYAVMA KNCMHGFTIP EEEGGGKSGT RIKIKYERKI KFSVIKDWIL NHPRIVIPAI
AALIAAITVT IFDPIRTFFI EMKIKATLQT EENSVLQWIR NQANKANIIY FGRQRTDPRR
LTAIWEDRQG DIKQLQSWLM ENAETFIVIH GPRGTGKREL VLDRALENYK YKVVIDCKQI
QDAKGDTAKI ARAASQVGYR PVFSWMNSMS SFIDLAAQGM IGTKAGFSET LDAQLSKIWQ
NTATALKRVA LSNRKKDDKE AHLSDEEYLE AHPEQRPVVV IDNFLHNATE SSVVYDKITE
WAAGLTTGNI AHVVFLTTDV SFSKPLSKAL PNSVFRTISL GDCSLDVGRK FVLSHLEHGA
KDGANSGQNM EEVGDLGTLD SCIEVLGGRV TDLEFMARRI ESGETPRAAV NRIIEQSASE
ILKMFVFDPD IESKQWSHEQ AWHLIKTLAH SQDGTLPYNQ VLLSDLFKEN GETTLRALEQ
AELIAISSVN GCPDAVKPGK PVYRAVFKRL TENKTLSSRL DLDIVKQLLS SENKSIGKYE
QELQVLGSLP KQPRELSARI QWLLQKVASS QNKISQYEHE SAILQKVLRR EH