ID   YME2_ASPOR              Reviewed;         864 AA.
AC   Q2UBI2;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=yme2; ORFNames=AO090012000987;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; AP007161; BAE61083.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2UBI2; -.
DR   STRING; 510516.Q2UBI2; -.
DR   PRIDE; Q2UBI2; -.
DR   EnsemblFungi; BAE61083; BAE61083; AO090012000987.
DR   VEuPathDB; FungiDB:AO090012000987; -.
DR   HOGENOM; CLU_007861_1_0_1; -.
DR   OMA; NPIKPWF; -.
DR   Proteomes; UP000006564; Chromosome 4.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..864
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343115"
FT   TOPO_DOM        ?..330
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        352..864
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          223..315
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   864 AA;  97096 MW;  4604080B16D858D4 CRC64;
     MDDGGNDVDS AEDGDPCDAS CPLLMSPSKL ASNCFNSASA RSSRVNVRGC DTSFRWGRPP
     PSLFAAKSSL ARLSSASHAS YLETGHIDLK KNEGLLFINN IFPRKLQWVL EGSLRASRPY
     EEALKRIDRP HLAASDPLRI IRRVFPHELE VEIKEVVPRF REGGAFVKYT RNEGVKDTDI
     ETAVKDHLEK HPIRPWFNPF QQVKVASVLG RPWIEDLYRI PSPRLRVEFL PGSANDLAND
     PTTESLYSLF RSYGKLRDIE RQPSDSKILP RYAYVEFARP KFAVMAKNCM HGFTIAEKEG
     GGKFGTRLKI NYERKIKLSM IKDWILSHPR IVIPAVAALI AAITVTVFDP IRTFFIKMKI
     KATLHVEENS VLGWIRKQVS KANIIGLGVV ASDPRGLTAI WEDRQGDISQ LQSWLTENTE
     TFIIIHGPRG SGKRELVLDQ ALENYKYKVV IDCKQIQDAR GDTAKIARAA GQVGYRPVFS
     WMNSISSFID LAAQGMIGTK AGFSETLDAQ LSNIWQSTAT ALKGVILDSR KKNDKDAHLT
     DEEYLEAHPE LRPVVVIDNF LHNASEDNVV YEKITEWAAG LTSANIAHVI FLTTDVSFAK
     PLSKALPNSV FRTISLGDCS LEVGRRFVLN HLADEARTGD KPPRSEEYLE DLDSCIEILG
     GRVTDLEFMA HRIEAGETPN GAVNRIIEQS TSEILKMFIL STNTEAQWSH EQVWHLIKML
     ANSKEGSLPY NQVLLSDLFK ENGEVALQAL EQAELISVSS INGCPETVKP GKPVYRAVFK
     KLTENKTLSS RLDLEILSRL ISKENKSIGK YEEELRLLGS LPKQPRELTS RIQWLLQKVY
     NSQNKISRYE TESAFLQMIL RRGH