ID   YME2_CANGA              Reviewed;         848 AA.
AC   Q6FIK2;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; OrderedLocusNames=CAGL0M13761g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62922.1; -; Genomic_DNA.
DR   RefSeq; XP_449942.1; XM_449942.1.
DR   AlphaFoldDB; Q6FIK2; -.
DR   STRING; 5478.XP_449942.1; -.
DR   PRIDE; Q6FIK2; -.
DR   EnsemblFungi; CAG62922; CAG62922; CAGL0M13761g.
DR   GeneID; 2891233; -.
DR   KEGG; cgr:CAGL0M13761g; -.
DR   CGD; CAL0137425; CAGL0M13761g.
DR   VEuPathDB; FungiDB:CAGL0M13761g; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_007861_1_0_1; -.
DR   InParanoid; Q6FIK2; -.
DR   OMA; NPIKPWF; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:EnsemblFungi.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR039627; Yme2_C.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..42
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           43..848
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343118"
FT   TOPO_DOM        43..284
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..848
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          196..269
FT                   /note="RRM"
FT   REGION          603..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   848 AA;  97863 MW;  B74DEAA68EA8E35C CRC64;
     MNSITTPRMG ATILRTIAPN VGVLSQVLPL GLRRVYPRGV RWVSSEIQQK DRQAGESNTA
     TDTGVIHKTE QETLLYFDNV YARATSLWNP ALWYNVLLRN QSRESVREKI KNLASPPDNP
     IHGLQLRSTI PVKRDGGVFA TFLVPFNYTK AEVNTMIQQN TLNESKNSLF SYFTRATAFP
     VKGSPWIEDL KRLPSTTVII KCQGPPLTEE EIYSLFRRYG TIIDIFPPND TNKHFRVKYR
     SYRGAICAKN CVSGIEIHNT VLHLQYENVV KGHLIRNFYV THTRIAIPVT FALLSILAVL
     IFDPIREFFI EQKITHQYQI SWDNRYLKQL KNLTNSTVST FKNYWGYDSS IISKRHLWEE
     RIEKMDDLKM WLEENNNTFV LIRGPRGSGK HELVMQHTLH NRNNVLYIDC DKLIKSRTDA
     KFLRNAAGQL GYFPIFPWID SVTNVLDLMV QGLTGQKSGL SETKESQFRN MLTTSLMAVR
     RIALKDYQST INDAGDDVNI KEEDYLQQHP EAKPVIVIDR FEGKADINSF VYKELADWAA
     MLVQMNIAHV IFLTETVAAN QRLSESLPNQ VFKTMILSDA SKANSRNYVL SELVEHYHKS
     LKRAKKAEED EPTEKASPEH SQYDENDPRR YLSEELIQDI DDSLEPLGGR MLDLQAFVRR
     VKFGELPKEA LDKMIEQASE QITQIFLSDK IDPLKSAQAW ELIDLLSKNG KVYFHDIVFR
     PLFKAAPEIG ILELENNGLI TVSRDRGVLK EIRPFKPLYR AAFQYLIDDE DLKTVLMTRY
     HLKVINFETG RIKKWEEELR ALGKINDQKL FKSRLDYLSK KITTSSDVIN HCEDEIKKLS
     QESNNRRK