ID   YME2_CHAGB              Reviewed;         831 AA.
AC   Q2GUU0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; ORFNames=CHGG_08264;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; CH408033; EAQ87011.1; -; Genomic_DNA.
DR   RefSeq; XP_001225920.1; XM_001225919.1.
DR   AlphaFoldDB; Q2GUU0; -.
DR   STRING; 38033.XP_001225920.1; -.
DR   EnsemblFungi; EAQ87011; EAQ87011; CHGG_08264.
DR   GeneID; 4393342; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_007861_1_0_1; -.
DR   InParanoid; Q2GUU0; -.
DR   OMA; NPIKPWF; -.
DR   OrthoDB; 213553at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..48
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           49..831
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343119"
FT   TOPO_DOM        49..301
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        323..831
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          196..286
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   831 AA;  92715 MW;  9D8307B14AC2343A CRC64;
     MISGRVLYRP AGRRGVGPLP LAATTYALRR RSPSITALGQ PRRLIRRWES TSGAVGSDNS
     GHIDTQPNES ILFFDNIFPL KLSSVLLWRA WETNELLRRF NSASLSFLDP IGLVKRAIPE
     SAPIKVTEII PRLKEGGAYV KFTYPDSISP ADIEDQLVKY HEKTPIKPWF NPFRTIKSRL
     VLGRPWLEDL YRLPKSRLKI EFVPAKNSEP PTELSQESLY SLFRRYGKIS DITSQAPDSK
     VLPKFAYVDF VLVRDAILAR NCIHGFVLQE EGSKSLTRLR LSYEQRVKAH HIWNWVTGHP
     RIVIPVIAAF LAAFTVAVFD PIREFFVKRQ TSDILAFRKR GDDDAGLSAL FTHRKDLIDS
     IQNNLLETVG TFIVVQGPRG SGGRELVMDQ VLEGRRDVLV VDCRQVVEAR GEAGTIRKLA
     NQVGYRPVFS WANNLSSMVD LAIQSTTGVK AGFSENLESQ VTKILQTTAE ALKDVSLARR
     KRDKDANLTD DAYLEAHPER RPVIVIDNFL HKSEEKGIVY DKISDWASAL VQANIAHVIF
     LTTDTSYSKP LSKALPDRVF HQITLGDLTP EVAKHFVVSQ LETDEDADEK KNGASPAISE
     RKLRRDLQEL DECIDALGGR LTDLQVLARR LKVGQSPKKA VSDIIDQSAS EILRMFLLTN
     KGAGSGDKKW STEQAWYLIK QIASKESLRY NEVLLSDTFA SSTTADASNA EAALESLANA
     ELVTIKSHHG RPATIRAGKP VYQAAFNRLL DDAVVNARMD LAVLTELAKI EAKKIDKAEG
     ELSVLGSLPS QPYQTADRVN YLLAKLQGSQ EKIVAYEKEM AGLKKVLSEE A