ID   YME2_COCIM              Reviewed;         839 AA.
AC   Q1E4N0; J3KLV8;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; ORFNames=CIMG_02483;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS37129.3; -; Genomic_DNA.
DR   RefSeq; XP_001248712.1; XM_001248711.2.
DR   AlphaFoldDB; Q1E4N0; -.
DR   STRING; 246410.Q1E4N0; -.
DR   EnsemblFungi; EAS37129; EAS37129; CIMG_02483.
DR   GeneID; 4567783; -.
DR   KEGG; cim:CIMG_02483; -.
DR   VEuPathDB; FungiDB:CIMG_02483; -.
DR   InParanoid; Q1E4N0; -.
DR   OMA; NPIKPWF; -.
DR   OrthoDB; 213553at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   mRNA processing; Reference proteome; RNA-binding; Transit peptide;
KW   Transmembrane; Transmembrane helix.
FT   TRANSIT         1..42
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           43..839
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343120"
FT   TOPO_DOM        43..297
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        319..839
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          190..282
FT                   /note="RRM"
FT   COILED          769..838
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   839 AA;  93614 MW;  681F06F688230F13 CRC64;
     MIQFSGRACL RQGWKCAAGV GLRCHGAHSS PPLHVPPFRR YTATYSRADE TGHIDTAPNE
     SVFYFDSVLP VKALFSRRFA PLDLAPSMTG RIGNLIIKLT GATPLNVIGR AFPLELQENI
     QQVIPRYSEG GAFVKLSHPP NMDKEGLSSL LNTHLEQNPL KLWFSPFTSV RASLVRGRPW
     LEDLQRSPSS RIKVEFLPTS PGASSVELTP ELLYSLSRRY GKLADIIPQP SDSKIQPRYA
     LLDFTRPSYA VIAKNCLHGY KVSASEGGGS AGTLLKLSYE RKLKPHVIRG WIVSHPRIVI
     PIIAAVIAAI TVIVFDPIRT FFIKIQIAPP IDVQDNRLWQ WIQRQASKAN DILSLRQRQR
     SDSRGLKAIW EDRKEDIQRL QTWLLEATNT FTVVHGPRGS GKKELVLDEV LKGYRHKLVI
     DCKPIQEARG DSATINAAAA EVGYRPVFSW MNSISSLIDV ATQTLGANAG LSETLDSQLG
     HILQNTANAL KKVALEKKRW DGKDSHMTDE EFLEAHPECR PVVVIDNFLY KANNNPMIYE
     KLSDWAAALT VSNIARVIFL TGDISYSKTL SRALPNQIFH EIQLGDCTPD VAKQFVLDHL
     HTDQSNSSSY TQAGPDTIEG GDIKDLEDCI EVLGGRLSDL EFFARMISRG QSPSDAVHDI
     IVQSAAEILK MYIADVDNTV RNWTPEQAWY LVSSLAEAQG GSILYSEALF SDLFKKDGES
     TIRALEQAEL ISVTTLNDRP STIKPGRPVF AAAFRRLLED DVLRCRLGLR TLGQQIAMEN
     ANINKYEGEL QVLGSLEKEP KEIRPRVRWL LEKLAGSQAK IEKYEKESVG LRRILQSKM