ID   YME2_DEBHA              Reviewed;         860 AA.
AC   Q6BKQ1;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; OrderedLocusNames=DEHA2F20108g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; CR382138; CAG89608.2; -; Genomic_DNA.
DR   RefSeq; XP_461220.2; XM_461220.1.
DR   AlphaFoldDB; Q6BKQ1; -.
DR   STRING; 4959.XP_461220.2; -.
DR   EnsemblFungi; CAG89608; CAG89608; DEHA2F20108g.
DR   GeneID; 2904039; -.
DR   KEGG; dha:DEHA2F20108g; -.
DR   VEuPathDB; FungiDB:DEHA2F20108g; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_007861_1_0_1; -.
DR   InParanoid; Q6BKQ1; -.
DR   OMA; NPIKPWF; -.
DR   OrthoDB; 213553at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..12
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           13..860
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343121"
FT   TOPO_DOM        13..270
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..860
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          180..255
FT                   /note="RRM"
SQ   SEQUENCE   860 AA;  99339 MW;  D6DF496D1D7FE490 CRC64;
     MSGYQRPFIR NYASDVEDLK KEADRLETDK SASTTGVLDY EKQSEVVLYF DHIYPMPISG
     LSLKRKFLSP IQNRVTTDDL KQKVLDLSST DSNPLPENTK ISEFVPLKRD AGAFVKFEVP
     PETTCKELIN QIVSNLEENE VQHNKNIFNY VKNLFWNKFP KCYQVKGTPW IEDLRRYPSP
     KLKVIFEGDP LTEEELYLLF RRYGLIVDII PVSSSNPTAT IIFKYLRSAV CAKNCITGIS
     LNSSMTTLHL QYIPIERVNY LMDFIVNHQK ITIPAIVALL ATLAVLIFDP IRQLFIEQHI
     THKYSLETYK DNRYVKVVYY PYRSLVQWLN NSYDYIDEKL NQVYEGKGDL EVTSEDSENI
     NILWNERFEK IKQLKLWIYE NINTFIVVKG PKGSGKEEFV LDHTLNNDEK LKRKVLYIDC
     DALVKARSDN GLIKTTARQL GYFPVFTWTN SISQFVDLGV QGLTGQKSGL SESKETQLKN
     MFSLTTQALR NIALSDYEDY RNDTIKQQKR RTRKTENNTD EKPSISVEEE IIKEEDYLQQ
     HPEAKPIIVV NNFQRKSDGN NDMIYKLIAE WTSSLVQSNM SHVIFITHDV GSVQHLTDSL
     PNQVFKTISL SDASQRSAKQ YVWNQLNDPS LMNPDSLDKY IEPLGGRMLD LQAFIRRIKS
     GESANDALSE MVNQASEQIT TFFLNNTVAN ESDSNWNTAQ VWAIMKFLSE NDSFEYNELS
     KISLFKSSNE TLATLAALEK HDLISFTREK GVLSRISTGR PLYKAAFKEL INDRKVYKLY
     ETDYYNNLIT IESTKIFKLE DEINKISRLS DIKYLKNRLE YVSSKINTAT ETIMKYEEKI
     KEIGKLNEKS SSSFLGIKFN