ID   YME2_DICDI              Reviewed;         878 AA.
AC   Q54K38;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Mitochondrial escape protein 2 homolog;
GN   Name=yme2; ORFNames=DDB_G0287621;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome. May
CC       have a dispensable role in early maturation of pre-rRNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000103; EAL63619.1; -; Genomic_DNA.
DR   RefSeq; XP_637126.1; XM_632034.1.
DR   AlphaFoldDB; Q54K38; -.
DR   STRING; 44689.DDB0187555; -.
DR   PaxDb; Q54K38; -.
DR   PRIDE; Q54K38; -.
DR   EnsemblProtists; EAL63619; EAL63619; DDB_G0287621.
DR   GeneID; 8626221; -.
DR   KEGG; ddi:DDB_G0287621; -.
DR   dictyBase; DDB_G0287621; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_327739_0_0_1; -.
DR   InParanoid; Q54K38; -.
DR   OMA; NPIKPWF; -.
DR   PhylomeDB; Q54K38; -.
DR   PRO; PR:Q54K38; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   mRNA processing; Reference proteome; RNA-binding; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..878
FT                   /note="Mitochondrial escape protein 2 homolog"
FT                   /id="PRO_0000343122"
FT   TOPO_DOM        1..338
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        360..878
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          229..323
FT                   /note="RRM"
FT   REGION          99..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          761..873
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        99..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   878 AA;  101257 MW;  EF36F0DFD3D98256 CRC64;
     MASPSSRLLK FITNGSKLHS AKNNNMIKNK NIISPTITKL FSTSKISNEI GNIRNFNNKI
     STNLINSNIN TKPFFEIPKL FEKKYYSYIP PTWEEKDKEK QFNSITSTRE EGGDNEESNR
     MGNGSIKDAI VWVNHLYPIK VSRLDFRSLF FHIPITKKLN SLFPNDVKII SIEKRIKEGG
     AYIHFQYDSS NPEYKSIEMV MSKLKSIFAQ EKKHFHFASR PAKCKLVYGR PFVEDIDYRF
     PSTTLKITFK GSEMSPDDLF RLMRPYGHIK DIHYSSPIPS KDGPRQATIT FKRMEGAIAT
     RNCLHNKYFP EFNTSLYMDY EQLMRINKLK EQFSKHPKIM IPLLGILATL LTLLLFNPLR
     EYFINKKLSS PCYFGEQEED DWQERSEQKV LQTHFNFPPN SIVMISAPKG SGKSSLIDKV
     LENRINTLLI DCNQEVNNND EEFIESFSKD IGFSPSYSLY SSFGSVIDAI IPTGKGAFHS
     TTNYQMQTIL KLLDEVLAKK AKQFPVDPHQ PYEYPLIVID GFFGMIQAME SKEKANIIMD
     SVIQWAITST QRGHAHVVFL SSDSFAGDII KKYLDNRGGG QISTIQLGDV QPSMAINYIK
     KRIGPNTPIT QHDMELVVDN LGGRYYDLNV LSQRMIAGDS VERALSNMIS KAVSEIRAEG
     FGLSKRNDDS KIGGTKLKWS RPQLWETIKK IAENDFVSYD DLLFNVFLGD ESSLNNLISS
     NLLRFQNVDN ERKVTAYSPL YCSAFKQMVN DLEFNVGMDV LVQKARIEEE LSKLSKVEDE
     LLKIKNLTSK SWFEPLSIKK RRILLEDKLK DHVAKIEHRE NILKKHSLFQ KFLREEQMIQ
     MELIKKQREQ SKFERQQQQL LQQQQLQQQQ QQQQQGSI