ID   YME2_KLULA              Reviewed;         808 AA.
AC   Q6CTB6;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; OrderedLocusNames=KLLA0C13948g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01674.1; -; Genomic_DNA.
DR   RefSeq; XP_452823.1; XM_452823.1.
DR   AlphaFoldDB; Q6CTB6; -.
DR   STRING; 28985.XP_452823.1; -.
DR   EnsemblFungi; CAH01674; CAH01674; KLLA0_C13948g.
DR   GeneID; 2892450; -.
DR   KEGG; kla:KLLA0_C13948g; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_007861_1_0_1; -.
DR   InParanoid; Q6CTB6; -.
DR   OMA; FQFFRPY; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:EnsemblFungi.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..30
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..808
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343123"
FT   TOPO_DOM        31..271
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..808
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          184..256
FT                   /note="RRM"
SQ   SEQUENCE   808 AA;  92635 MW;  0317A70197D2D66C CRC64;
     MFLSRSIPQA FSLRYTTRYG KLILRPGRRF VSSEIQQKDE QAGESNTATD TGIIHKTEQE
     TLIYFDNVYP RAMSLWSPTQ WYNLLMSNQT RNAVRAKIFK FANPPDNPIH NLELRSTIPI
     KRDGGVFATF LVPPNYTTAE VNAMIQKNTQ QESSKSWFSF FTEVTAFPVK GSPWIEDLRR
     LPSNQIRVKF EGGFLTEEEV YALFRRYGTI INIYPNPKEM TYLISYRSFR GAICAKNCVS
     GMEVHNSIIH VQYEQLTQGH VISDFFVNHT RIAVPLLLAL LSILAVIVFD PIREFTIEQK
     ITHKYSLSWD NYFLKKILSV TSSTMSSVKE YWGITDRHVQ KRQLWEERQE KVADLKLWLQ
     ENNNTFVVLR GPRGSGKHEL VMQHTLHDRP NVLYLDCDKL IKSRTDAKFL RNAASQLGYF
     PIFPWVNSVT NLLDLAVQGL TGQKSGLSES KELQFRNMLS TAMMSIRHIA LKGYKPVIGS
     GDSIINVKEE DYLQQHPEKK PVIVIDRFNN RAEMNGFVYK ELSDWAAMLV QMNLAHVIFL
     TETVSPNQLL AESLPNQVFK MMTLSDASKK SARRYVLAQL QETTEDDDDI DTSKPLDLNE
     KFVHEIDDSL DPIGGRMLDL QAFVRRVKSG EQPKEALEKM VEQASEQITQ IFLSGSADPL
     RGAQAWELIE LLSANGSIRF RDIIYRPLFK AAPEAALLDL EKNGFVTMTR DRGVLTDIYP
     AKPLFCAAFQ YLLNNKEMYN VLRTSYLLRM VTFETGRIKK WEEELRALGK VSDQKMFRSR
     LAYLAGKIDA SSAAIDDCES EVKELSKK