ID   YME2_LODEL              Reviewed;         862 AA.
AC   A5DSF0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; ORFNames=LELG_00286;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; CH981524; EDK42108.1; -; Genomic_DNA.
DR   RefSeq; XP_001527766.1; XM_001527716.1.
DR   AlphaFoldDB; A5DSF0; -.
DR   STRING; 379508.A5DSF0; -.
DR   EnsemblFungi; EDK42108; EDK42108; LELG_00286.
DR   GeneID; 5234934; -.
DR   KEGG; lel:LELG_00286; -.
DR   VEuPathDB; FungiDB:LELG_00286; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_007861_1_0_1; -.
DR   InParanoid; A5DSF0; -.
DR   OMA; NPIKPWF; -.
DR   OrthoDB; 213553at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   mRNA processing; Reference proteome; RNA-binding; Transit peptide;
KW   Transmembrane; Transmembrane helix.
FT   TRANSIT         1..36
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           37..862
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343124"
FT   TOPO_DOM        37..282
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        304..862
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          176..267
FT                   /note="RRM"
FT   COILED          820..847
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   862 AA;  99075 MW;  C01B6E7491C1F4DD CRC64;
     MMRLKILRAS RINPALLRLR PPHLYSINKS QAFRFYATDI EDLKRQSDRT ESDNSASTTG
     VIDKEANEVL LYYSFSNSRN FVKQYISRFL PSKFLGEQVE EKVKDVSYPL PQNSSITEVL
     HLPRDSGAFV KFKYSPSLTA KEFIQDIRSN IAESNTKRYS NIFMKAIGFV WDRSTQVYTV
     KGVPWIEDLK RFPSQKIGIT YEGNPLTEEE LYVLFRRYGL IDDIKVESTQ SFVLFDTVRA
     AICAKHCITG MQLNGGKTTI HIQYVPVKKT NFIIEMISSH TKIALPIILA LLATFAVLIF
     DPIREWFIQL KITRASHSFD EFKENKWFKI VYIPYKQLLN AVSSGYDYID TQLHEVTGIN
     NVDECLDDNQ VLQEKNWESN MFWRERFEKA KQLKLWIMEN IDTFIIVKGP QGSGKEEFVV
     DHTLMADAKL RKKVLLLECD ELSKARSENS LIASTASQLG YFPVFTWTNS ISQFIDLGLQ
     GLTGQKSGLS ESKETQIKNM FSLATQAIRS LTDGDYNKYK TNIEKKNRRL KDDEKIEVLR
     LEEFLAQHPE SKPIIVINKF ARKADVLSND FIFPLIADWA SGLIQNNIAH VVFTTADVGS
     LQHLNDALPN QVFKNISLSD ASIASSKQYI CDALKMKDTA TLDDCIAPLG GRMLDLQAFI
     RRIKSGEDPL QAIDEMVNQA AELITTFFLH EHKFSNDDSN WNPSQVWLIM KLLSKKDVID
     YDSLIKLPLF KQSKETLDTL STLEKYDLVS LKREKGVLSK ILTGRPLFTA AFENIISDVR
     IWKLYETQYL LNLVSLEVQK LTKFENELTT IYKINKLDGR IDYLSKKIDE SNQKIVDYEK
     EIKDIAAYKG EPKQRHSFLG IF