ID   YME2_MAGO7              Reviewed;         901 AA.
AC   A4R1D5; G4MNU2;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; ORFNames=MGG_06965;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; CM001231; EHA57099.1; -; Genomic_DNA.
DR   RefSeq; XP_003709711.1; XM_003709663.1.
DR   AlphaFoldDB; A4R1D5; -.
DR   STRING; 318829.MGG_06965T0; -.
DR   EnsemblFungi; MGG_06965T0; MGG_06965T0; MGG_06965.
DR   GeneID; 2685138; -.
DR   KEGG; mgr:MGG_06965; -.
DR   VEuPathDB; FungiDB:MGG_06965; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_007861_0_0_1; -.
DR   InParanoid; A4R1D5; -.
DR   OMA; NPIKPWF; -.
DR   OrthoDB; 213553at2759; -.
DR   Proteomes; UP000009058; Chromosome 1.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..59
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           60..901
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343125"
FT   TOPO_DOM        60..332
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        354..901
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          226..317
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          644..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   901 AA;  100022 MW;  37A72AAD98FCB71B CRC64;
     MIGGTRLLPF RLLAFGPAAT RQPTTALRRS RVTLTGAPRG IYLGLGSGSG LNINNRRWES
     TTATTATASS SRPKSDDVAA EVDYGHIVPR ANEAALYFDN IFPLGLSAIL WRRWGTDEDF
     SEQLLKRFEK SSFGFGITDP ISMVKRSIPK SLPIKVTEII PRLKDGGAFV KFSHGPETTP
     AEIEESLAKS LQDRPVKPWF NPFTSVRVNA VKGVPWLEDL YRLPKARLKV EFCPPKELSK
     DSTSTELSQE ALYGLFRRYG KLSEITPQPS DSKVTPRFAH VDFVRVRDAV MARNCLHGLT
     ISQDNSATRL RLSYEQKVKP HKIWEWTTSH PRIVIPILAA LLAAFTVVVF DPIREFFVRA
     HVQGSFRVSN SRLYRWFKRR TADVTNSVFQ RHHDKGEQAG LQALWSQRKD IIDSVQKWLL
     ETADTFIVVQ GPRGSGTKEL IIDQALKGRP NVLVIDCKPI VEARGESGTI RKLAVAVGYR
     PVFSWANSLS SMIDLAVQGT TGVKSGFSET LESQIVKILH TTASALKKVS LEQYQKDGSG
     AEISEDAYLE AHPEKRAVIV IDNFLHKHDD GGLVYDKIAE WAAAMVQSNI AHVVFLTNDS
     SYSKSLSKSL PDRIFRQVSL GDLSASVAKK YVLGHLEGLD RDESLKDDSS EVSRDDKGAE
     NPSEDDIEAE SKRRRDLAEL DGCIDTLGGR LTDLEFLARR LKSGQSPRNA ISEIVDQSSS
     EIIKMFLLAK KSTESTQTQW SAEQAWFLIK EIASKTSLRY NEVLLSPTFA SSTTPSAADG
     EAAIEALAAA ELVTVTSHRG RPQTIRAGRP VYQAAFTQLT QDAVLKARMN LLLLTELSKV
     EAKNIDKVET ELALLGALPK QPREVTDRVT YLLGKLHSSQ VKISELDREM AMLKGVLVRE
     V