ID   YME2_NEOFI              Reviewed;         869 AA.
AC   A1D3P4;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=yme2; ORFNames=NFIA_017380;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW23037.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; DS027688; EAW23037.1; ALT_FRAME; Genomic_DNA.
DR   RefSeq; XP_001264934.1; XM_001264933.1.
DR   AlphaFoldDB; A1D3P4; -.
DR   STRING; 36630.CADNFIAP00002147; -.
DR   EnsemblFungi; EAW23037; EAW23037; NFIA_017380.
DR   GeneID; 4591789; -.
DR   KEGG; nfi:NFIA_017380; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   OrthoDB; 103839at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..869
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343126"
FT   TOPO_DOM        ?..334
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        356..869
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          227..319
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   869 AA;  98686 MW;  4FAD3883C88F4914 CRC64;
     MIDVISRYQA SPLIESTLGY QSITIIFGNA HLQSSKKNVI LAAMMRTRIP GLVPRICQTP
     LPWKPPTQLT RVRYARWSTS HAVSWFETGH IDLKENEGLL FINNIFPSKL QWLLRGPLGG
     MRSYEEAVKR IDRPQLAASD TFQIIQRVVP KNLNIQVKEV VPRFREGGAF VKYTRPSNVN
     DADIEASIKE NLKEHPIRPW FNPFQEVQVC RVIGRPWIED LYRLPSPRLK VAFHPVSPEA
     SAADLNTETL YTLFRPYGKI RDIEKQPSDS KVTPRYAFVE FSRPKYAGMA KNCMHGFTVP
     EQEGGGKSGT RLKIKYERKI KLSMIKDWLL SHPRIVIPVL AALLAAITVT IFDPMRTFFI
     KLKIKSTLQT EENGVMQWIR KQVNKANIIY FGRKGADPRG LTAIWEDRQE DITRLQSWLM
     ENVETFIVVH GPRGSGKREL VLDRALVDYK YKIVIDCKQI QDARGDSAKI ARAASQVGYR
     PVFSWMNSIS SFIDLAAQGM IGTKAGFSET LDAQLSNIWQ NTATALKKVT LEHRKKNHKD
     SHLTDEEYLE AHPELRPVVV IDNYLHNASE SSVVYDKITE WAAGLTAGNI AHVIFLTTDV
     SYAKPLSKAL PNSVFRTITL GDCSLEVGRK FVVNHLAYES KDGKTQPRRA EELEDLDACI
     ETLGGRVTDL EFMAHRIEAG ETPRGAVNRI IEQSASEILK MFLLTPETIE QSWTHEQAWY
     LIKRLAESKD GALSYNEIVL SELFKENGEI TLRALEHAEL ISIAAVNGCP QTIRPGKPVL
     RAAFKKVTEN KALSSRMDLA IITQKINKEN KSIGKYEEEL SLLGSLPRQP RELTDRIQWV
     LNKVYSSQNK IAKYEKESAY LQKILRSEH