ID   YME2_PICGU              Reviewed;         874 AA.
AC   A5DAI1;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; ORFNames=PGUG_00286;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; CH408155; EDK36188.2; -; Genomic_DNA.
DR   RefSeq; XP_001486909.1; XM_001486859.1.
DR   AlphaFoldDB; A5DAI1; -.
DR   STRING; 4929.XP_001486909.1; -.
DR   EnsemblFungi; EDK36188; EDK36188; PGUG_00286.
DR   GeneID; 5129298; -.
DR   KEGG; pgu:PGUG_00286; -.
DR   VEuPathDB; FungiDB:PGUG_00286; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_007861_1_0_1; -.
DR   InParanoid; A5DAI1; -.
DR   OMA; FQFFRPY; -.
DR   OrthoDB; 213553at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..55
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           56..874
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343129"
FT   TOPO_DOM        56..313
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        335..874
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          224..297
FT                   /note="RRM"
FT   REGION          547..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   874 AA;  99349 MW;  91BA31A909512477 CRC64;
     MIRTFATIAN RGPGIRLATL AASRNLGYSS GGRISSVRIE KLRFSPFRSS TSLRYTSDIQ
     HVMQEADSLD VNNSVSNTGV LDYDRKNAVV LYFDHIYPFS VSRYSWKQYF TLLFPVNRCS
     EDDIRERVMN LSSTEKEPLP KDVRILELVP MRRDGGVFVK FQLPATMSAR ELVGLICQNT
     KENEQAYGER FLVGPLNKIW NHFPRCFQVK GTPWIEDLRR FPSVKLSVKF EGERLTEEEL
     YVLFRRYGLI IDIAPGSGTE PAVIHFRKIR SAICAKNCVT GITLNSGNTV VHIQYLPLKR
     VNYITDFIGN HQRIAIPIIL ALLATAAVFI FDPIREWFIM QNVSHRHALD SYKDNKFLKL
     VSLPYEQVRR WIDSGYDYFD SKFGCDEEDE FGGEKGEAPN DLWSERYEKV KQLKLWIYEN
     INTFIIVRGP KGSGKEELVL EHTLRDDPIL GNKLLYIDCE ALVKSRSDNA LIEATAQQLG
     YFPVFTWTNS ISQFVDLGVQ GLTGQKSGLS ESKETQLKNM FGLTSSAIRK LALQDYAKYK
     KSVLRQRRRQ QGDSTSEDIL SEDEYLSQHP ERKPVIVIDK FAGRADGDQD FIFKMISEWS
     AQLVQSNLAH VIILTHDVGS MSHLTSALPN QVMKSISLSD ASQRSARHYV LNQLNKESQA
     QVNELDSCLE PLGGRMLDLQ AFVRRMRSGE APGDALEEMV SQASEQITTF FLSASSTQNS
     WSTAQVWLLI KLLAKQESIS YETLCHDPLF KSPDSLSILS TLEKHDLISL ISDKGVLNTV
     STGRPLYKAA FRSLVEDPKI FRIYEEDLYN KLIALENAKI AKLEDEFAKL ASVDARLVRN
     RLDYVSNKIV ASTDKITDYE EKISGLSSKK SSWF