ID   YME2_PICST              Reviewed;         877 AA.
AC   A3M0D8;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; Synonyms=PRP12; ORFNames=PICST_33874;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; CP000502; ABN68505.2; -; Genomic_DNA.
DR   RefSeq; XP_001386534.2; XM_001386497.1.
DR   AlphaFoldDB; A3M0D8; -.
DR   STRING; 4924.XP_001386534.2; -.
DR   EnsemblFungi; ABN68505; ABN68505; PICST_33874.
DR   GeneID; 4840908; -.
DR   KEGG; pic:PICST_33874; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_007861_1_0_1; -.
DR   InParanoid; A3M0D8; -.
DR   OMA; NPIKPWF; -.
DR   OrthoDB; 213553at2759; -.
DR   Proteomes; UP000002258; Chromosome 8.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..47
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           48..877
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343130"
FT   TOPO_DOM        48..302
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        324..877
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          213..286
FT                   /note="RRM"
SQ   SEQUENCE   877 AA;  99336 MW;  619F733959DD136E CRC64;
     MISSSRVAAM ALRQSSRAIV PLAVLSSNGL RSRYFTPGLA HKTQIRTVTS DIAEIKQEID
     KDESDNSAET TGVIDVKNQH EVVLYYDHIY FLGASSPAYF NVFLQFLRIR KQTPAQIRDK
     ILKVSAPIPA EAEITQLIPF MRDCGAFAKF QVPPGVEVAE FVQQIRQNVV HNEKAYNSGI
     FRRVLSLFWS HYPAVYSVKG TPWIEDLRRY PNTKLKVKFE GEPLTEEELY VLFRRYGPLV
     DIIPGPESAE ATLIYRGLRS AIAAKNCITG VSLNKGRTVL HLQYIPIKRV NYITEFVTNH
     QRIAIPIILA LLATLAVLIF DPIRQYFIEV KITKRYSFDT YKDYAVVKTI TKPLRVVHNW
     LSSSYDYIDK KIDSISSPGT ASDEKSDDSD VSQALQTAST IWNERSEKSK QIKMWIYENV
     NTFIIVKGPK GSGKEEFILD HTLLNDEKLR HKILYINCSE LAKARSDNDL LKSTANQLGY
     FPLFTWTNTV SQFVDLGVQG LTGQKSGLSE SKETQLKNMF TLTSQAIRSI ATRDYQKYHA
     SVTRKNNRLP EGENIEILKE EEYLQQHPEC KPIVVIDKFN RKADAASNDF VYPMIAEWSS
     VLVQNNLAHV IYVTSDVGSI QHLNNALPNQ VFKSISLSDA SSFSAKSFLM HQLKLEDDHT
     ISGAFEPLGG RMLDLQAFVR RINSGETPPE ALEEMVNQAS EQVTTFFLCA HKIDDDTNWN
     AAQVWMLMKL LSKSDSINYS DLNKSPLFKP EEDTVATLTT LEKHDLISLQ RDKGILDKIS
     IGRPLFKAAF KQLISDPKIS KLYEVDYIST LIKIENEKIK KFEGELISIQ KLGDKLGSRV
     LYLSKKIDAS NAKVVEYEGK IAEINSKPAS KNFLKLF