YME2_SCHPO
ID YME2_SCHPO Reviewed; 773 AA.
AC O94689;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Mitochondrial escape protein 2;
DE Flags: Precursor;
GN Name=yme2; ORFNames=SPBC83.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC controlling the mtDNA escape. Involved in the regulation of mtDNA
CC nucleotide structure and number. May have a dispensable role in early
CC maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB36867.1; -; Genomic_DNA.
DR PIR; T40694; T40694.
DR RefSeq; NP_595637.1; NM_001021531.2.
DR AlphaFoldDB; O94689; -.
DR BioGRID; 277264; 15.
DR STRING; 4896.SPBC83.05.1; -.
DR MaxQB; O94689; -.
DR PaxDb; O94689; -.
DR EnsemblFungi; SPBC83.05.1; SPBC83.05.1:pep; SPBC83.05.
DR GeneID; 2540741; -.
DR KEGG; spo:SPBC83.05; -.
DR PomBase; SPBC83.05; -.
DR VEuPathDB; FungiDB:SPBC83.05; -.
DR eggNOG; ENOG502QS0P; Eukaryota.
DR HOGENOM; CLU_007861_0_0_1; -.
DR InParanoid; O94689; -.
DR OMA; FQFFRPY; -.
DR PhylomeDB; O94689; -.
DR PRO; PR:O94689; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; NAS:PomBase.
DR GO; GO:0000002; P:mitochondrial genome maintenance; ISO:PomBase.
DR CDD; cd12433; RRM_Yme2p_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR018850; Mt_escape_2_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR039627; Yme2_C.
DR InterPro; IPR034260; Yme2_RRM.
DR PANTHER; PTHR32198; PTHR32198; 1.
DR Pfam; PF10443; RNA12; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..29
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 30..773
FT /note="Mitochondrial escape protein 2"
FT /id="PRO_0000343131"
FT TOPO_DOM 30..249
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..773
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT DOMAIN 163..234
FT /note="RRM"
SQ SEQUENCE 773 AA; 88201 MW; 90BBE812071913ED CRC64;
MNLFLSRFTG LRNTSFLGHA RPFMFPRRYA HSLVAHNIGH IKLDPNEGLF FVDNLVNTPT
YFYIQRYTAL LFQNNLKKQL SAAFPSSDTM QLEDIIFRWQ DGGAFLKVRY KEFPQDTEAV
SEHVRESFRK RPVRTILHPF STPIPHMVHG IPWLQDLYIF PSRTVDVNFE GPPLSQERLY
SIFRTYGKLR SVTINSPTSA TLSFSSLRSA TSALNCMHGF VYGKTEFHMR YRHMNRFVAF
KDWLFSHPRF TIPLVAAAIT VLTASLFDPI RKFFVETNIV HGQKLRNINV VGWVKKKTRD
IVLSPFHENG TNIKAPIWTT REKDCEQLKE WLDEALHSFI VVQGPRGSGK RDLVDRVVKE
RKNVLFFDCD RLFSTTNTEM FVSTLASQTG YFPLFSFLNN ISSLIDMAAQ GLIGQKTGIV
SSSEGQVRQI LNTTQTVLRS LALREHKEAD TSVLDESEFL EVHADRLPVV ILDNFQLRKL
SNPMQRVVAE WAGNLVKEGI AHVLMLTPDV GGTKSLEQYV NGWENRTLLL GDADPVLAQR
YVIESLPEEM QTEELRKELR VQLPKIGGRL RDLDYVARRL RVNSSSVSEA IGGIVSQNAS
DILQTFLRPA SLTSEEKPTF TPEESWTLIT YLSQHEYIPY HMLMLDPLFK GHDDAVRALE
ESELITITTV NARPDKVYAG KPVYVTAFRQ LVNDPVLSAN MQLVRCNALI GMANNAIKND
EQELQMLKDL GNLESGVKDR AHYLTTRIQK NQGVITDNEK SIERLTEALK KID
