ID   YME2_VANPO              Reviewed;         830 AA.
AC   A7TML0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Mitochondrial escape protein 2;
DE   Flags: Precursor;
GN   Name=YME2; ORFNames=Kpol_513p24;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC       controlling the mtDNA escape. Involved in the regulation of mtDNA
CC       nucleotide structure and number. May have a dispensable role in early
CC       maturation of pre-rRNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YME2 family. {ECO:0000305}.
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DR   EMBL; DS480423; EDO16508.1; -; Genomic_DNA.
DR   RefSeq; XP_001644366.1; XM_001644316.1.
DR   AlphaFoldDB; A7TML0; -.
DR   STRING; 436907.A7TML0; -.
DR   EnsemblFungi; EDO16508; EDO16508; Kpol_513p24.
DR   GeneID; 5544662; -.
DR   KEGG; vpo:Kpol_513p24; -.
DR   eggNOG; ENOG502QS0P; Eukaryota.
DR   HOGENOM; CLU_007861_1_0_1; -.
DR   InParanoid; A7TML0; -.
DR   OMA; FQFFRPY; -.
DR   OrthoDB; 213553at2759; -.
DR   PhylomeDB; A7TML0; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12433; RRM_Yme2p_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR018850; Mt_escape_2_C.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR039627; Yme2_C.
DR   InterPro; IPR034260; Yme2_RRM.
DR   PANTHER; PTHR32198; PTHR32198; 1.
DR   Pfam; PF10443; RNA12; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; mRNA processing;
KW   Reference proteome; RNA-binding; Transit peptide; Transmembrane;
KW   Transmembrane helix.
FT   TRANSIT         1..41
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           42..830
FT                   /note="Mitochondrial escape protein 2"
FT                   /id="PRO_0000343132"
FT   TOPO_DOM        42..283
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        305..830
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          197..268
FT                   /note="RRM"
SQ   SEQUENCE   830 AA;  93981 MW;  55C090E6DEBC96A3 CRC64;
     MYRSGLLTSG GGSAALTALR AIGSRSSLSN GKFIWNVGKR FITSEIQEKD QQAGESNTAT
     DTGIIHKTEQ ETLVYFDNVY PRDTSLWNPA QWYNLLLVNQ SREAVRDKIT EFASPPSNPI
     HGLELRSTIP VKRDGGVFAT FLVPSKYTKA EVNAIIQKNT AEESSKSIFS FFTRASAFPV
     KGFPWIEDLR RLPTNTIKVL FQGPPLTEEE IYSLFRRYGT IIDIVPASDS VKNASVRYKS
     LKGAICAKNC VSGIEIHNTV LHIQYQQEAR NFVISNFFVN HTRIAIPVML AVLSIIAVLI
     FDPIREFSIE QKITHIYSLS WDNYWIRQIR NFTNSTVTSF RNYWGVNENA FAEKHLWEER
     IEKVNDLKMW LQENNNTFVV VRGPRGSGKN ELIMQHTVGD RTNVLYLDCD KLIKSRTDAK
     FLRNAASQLG YFPIFPWINS VTSVIDLMVQ GLTGQKSGLS ETKEAQFRTM LTTALTSIRR
     IALKGYKSVI VDGGEDVNVK EEDYLQQHPE AKPIIVIDRY EGKSEINGFI YKELADWASM
     LVQMNVAHVI FLTETVSSNQ QLSESLPNQV FKTLVLSDAS KENSRKYVLS QLQSFVDSKQ
     KSKEDIKITE NIEAEKSKIT DQIDDALEPL GGRMLDLQAF VRRVKSGEQP TEALDKMIEQ
     ASEQITQIFL SDKVDGIKSA QAWELIELLS AKSVVSYDDI VFKPLFKAAP ELGIVELENS
     GLITVSRNRG VLDKIRPAKP LYKAAFYYLV NSQELSTILR TRYLLKVITF ETGRIKKWED
     ELRPLGKSGD PKLFRGRFEY LSGKIETSNK VIVASEAEIK ALSERKQNQK