CBP1_ORYSJ
ID CBP1_ORYSJ Reviewed; 510 AA.
AC P37890; A0A0P0Y8R8; Q2QUQ3;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Serine carboxypeptidase 1;
DE EC=3.4.16.5;
DE AltName: Full=Carboxypeptidase C;
DE AltName: Full=Serine carboxypeptidase I;
DE Contains:
DE RecName: Full=Serine carboxypeptidase 1 chain A;
DE AltName: Full=Serine carboxypeptidase I chain A;
DE Contains:
DE RecName: Full=Serine carboxypeptidase 1 chain B;
DE AltName: Full=Serine carboxypeptidase I chain B;
DE Flags: Precursor;
GN Name=CBP1; OrderedLocusNames=Os12g0257000, LOC_Os12g15470;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Yukihikari;
RX PubMed=8161571; DOI=10.1016/0304-4165(94)90012-4;
RA Washio K., Ishikawa K.;
RT "Cloning and sequencing of the gene for type I carboxypeptidase in rice.";
RL Biochim. Biophys. Acta 1199:311-314(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of a C-terminal amino acid with broad specificity.;
CC EC=3.4.16.5; Evidence={ECO:0000255|PROSITE-ProRule:PRU10074,
CC ECO:0000255|PROSITE-ProRule:PRU10075};
CC -!- SIMILARITY: Belongs to the peptidase S10 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D17586; BAA04510.1; -; Genomic_DNA.
DR EMBL; DP000011; ABA96977.2; -; Genomic_DNA.
DR EMBL; AP008218; BAF29529.1; -; Genomic_DNA.
DR EMBL; AP014968; BAT16568.1; -; Genomic_DNA.
DR EMBL; AK064874; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; S43516; S43516.
DR RefSeq; XP_015618181.1; XM_015762695.1.
DR AlphaFoldDB; P37890; -.
DR SMR; P37890; -.
DR STRING; 4530.OS12T0257000-01; -.
DR ESTHER; orysa-cbp1; Carboxypeptidase_S10.
DR MEROPS; S10.004; -.
DR PaxDb; P37890; -.
DR PRIDE; P37890; -.
DR EnsemblPlants; Os12t0257000-01; Os12t0257000-01; Os12g0257000.
DR GeneID; 4351908; -.
DR Gramene; Os12t0257000-01; Os12t0257000-01; Os12g0257000.
DR KEGG; osa:4351908; -.
DR eggNOG; KOG1282; Eukaryota.
DR HOGENOM; CLU_008523_0_1_1; -.
DR InParanoid; P37890; -.
DR OMA; AIHAQPV; -.
DR OrthoDB; 607679at2759; -.
DR Proteomes; UP000000763; Chromosome 12.
DR Proteomes; UP000059680; Chromosome 12.
DR ExpressionAtlas; P37890; baseline and differential.
DR Genevisible; P37890; OS.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IBA:GO_Central.
DR GO; GO:0004185; F:serine-type carboxypeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0019748; P:secondary metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001563; Peptidase_S10.
DR InterPro; IPR033124; Ser_caboxypep_his_AS.
DR InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR PANTHER; PTHR11802; PTHR11802; 1.
DR Pfam; PF00450; Peptidase_S10; 1.
DR PRINTS; PR00724; CRBOXYPTASEC.
DR SUPFAM; SSF53474; SSF53474; 1.
DR PROSITE; PS00560; CARBOXYPEPT_SER_HIS; 1.
DR PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE 2: Evidence at transcript level;
KW Carboxypeptidase; Disulfide bond; Glycoprotein; Hydrolase; Protease;
KW Reference proteome; Signal; Zymogen.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..36
FT /evidence="ECO:0000255"
FT /id="PRO_0000004304"
FT CHAIN 37..510
FT /note="Serine carboxypeptidase 1"
FT /id="PRO_0000004305"
FT CHAIN 37..302
FT /note="Serine carboxypeptidase 1 chain A"
FT /evidence="ECO:0000250"
FT /id="PRO_0000274566"
FT PROPEP 303..362
FT /note="Linker peptide"
FT /evidence="ECO:0000250"
FT /id="PRO_0000274567"
FT CHAIN 363..510
FT /note="Serine carboxypeptidase 1 chain B"
FT /evidence="ECO:0000250"
FT /id="PRO_0000274568"
FT MOTIF 508..510
FT /note="Microbody targeting signal"
FT /evidence="ECO:0000255"
FT ACT_SITE 194
FT /evidence="ECO:0000250"
FT ACT_SITE 434
FT /evidence="ECO:0000250"
FT ACT_SITE 487
FT /evidence="ECO:0000250"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 418
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..399
FT /note="Interchain (between A and B chains)"
FT /evidence="ECO:0000250"
FT DISULFID 262..274
FT /evidence="ECO:0000250"
FT DISULFID 297..366
FT /note="Interchain (between A and B chains)"
FT /evidence="ECO:0000250"
FT CONFLICT 253
FT /note="D -> G (in Ref. 6; AK064874)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 55710 MW; 28896247FA1371CF CRC64;
MARRGRRSLA SPAVAIALFV FLAYGGGGGG GGVCEAAPAS AVVKSVPGFD GALPSKHYAG
YVTVEEQHGR NLFYYLVESE RDPAKDPLVL WLNGGPGCSS FDGFVYEHGP FNFESGGSAK
SLPKLHLNPY SWSKVSSVIY LDSPAGVGLS YSKNTSDYNT GDLKTAADSH TFLLKWFQLY
PEFLSNPFYI AGESYAGVYV PTLSHEVVKG LHDGVKPTIN FKGYMVGNGV CDTVFDGNAL
VPFAHGMALI SDDIYQEAQT ACHGNYWNTT TDKCENALYK VDTSINDLNI YDILEPCYHS
KTIKKVTPAN TKLPKSFQHL GTTTKPLAVR TRMHGRAWPL RAPVRAGRVP SWQEFARGSR
PSGVPCMSDE VATAWLNNDD VRAAIHAQPV SSIGSWLICT NVLDFIHDAG SMISYHKNLT
GQGYRAFIYS GDHDMCVPYT GTEAWTRSLG YGVIDSWRPW HLNGQVSGYT QGYEHGLTFA
TIKGAGHTVP EYKPQESLAF YSRWLAGSKL
