ID   YMOA_YERPE              Reviewed;          67 AA.
AC   P0A3X0; P27720; Q0WCE5;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Modulating protein YmoA;
DE   AltName: Full=Histone-like protein;
GN   Name=ymoA; Synonyms=hha; OrderedLocusNames=YPO3138, y1046, YP_0793;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
RN   [4]
RP   STRUCTURE BY NMR OF 2-67, AND SUBUNIT.
RC   STRAIN=195/P;
RX   PubMed=18001134; DOI=10.1021/bi701210j;
RA   McFeeters R.L., Altieri A.S., Cherry S., Tropea J.E., Waugh D.S.,
RA   Byrd R.A.;
RT   "The high-precision solution structure of Yersinia modulating protein YmoA
RT   provides insight into interaction with H-NS.";
RL   Biochemistry 46:13975-13982(2007).
CC   -!- FUNCTION: Modulates the thermoregulation of VirF, and hence the yop
CC       regulon, as well as the expression of the enterotoxin gene yst.
CC       Involved in chromosome structure and DNA topology; probably by means of
CC       compaction of DNA in conjunction with H-NS; probably requires H-NS to
CC       bind DNA (By similarity). {ECO:0000250|UniProtKB:P0A3X1}.
CC   -!- SUBUNIT: Monomer (PubMed:18001134). Interacts with H-NS, in the absence
CC       of DNA (By similarity). {ECO:0000250|UniProtKB:P0A3X1}.
CC   -!- SIMILARITY: Belongs to the Hha/YmoA/Cnu family. {ECO:0000305}.
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DR   EMBL; AL590842; CAL21733.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM84627.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS61058.1; -; Genomic_DNA.
DR   PIR; AB0381; AB0381.
DR   RefSeq; WP_002208622.1; NZ_WUCM01000009.1.
DR   RefSeq; YP_002348043.1; NC_003143.1.
DR   PDB; 2K5S; NMR; -; A=2-67.
DR   PDBsum; 2K5S; -.
DR   AlphaFoldDB; P0A3X0; -.
DR   BMRB; P0A3X0; -.
DR   SMR; P0A3X0; -.
DR   STRING; 214092.YPO3138; -.
DR   PaxDb; P0A3X0; -.
DR   DNASU; 1145993; -.
DR   EnsemblBacteria; AAM84627; AAM84627; y1046.
DR   EnsemblBacteria; AAS61058; AAS61058; YP_0793.
DR   GeneID; 61907009; -.
DR   GeneID; 67420002; -.
DR   KEGG; ype:YPO3138; -.
DR   KEGG; ypk:y1046; -.
DR   KEGG; ypm:YP_0793; -.
DR   PATRIC; fig|214092.21.peg.3595; -.
DR   eggNOG; ENOG5032SGA; Bacteria.
DR   HOGENOM; CLU_190629_0_0_6; -.
DR   OMA; RRCQSID; -.
DR   EvolutionaryTrace; P0A3X0; -.
DR   PHI-base; PHI:3819; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1280.40; -; 1.
DR   InterPro; IPR007985; Hemolysn_expr_modulating_HHA.
DR   InterPro; IPR036666; HHA_sf.
DR   Pfam; PF05321; HHA; 1.
DR   SUPFAM; SSF68989; SSF68989; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..67
FT                   /note="Modulating protein YmoA"
FT                   /id="PRO_0000201732"
FT   HELIX           3..11
FT                   /evidence="ECO:0007829|PDB:2K5S"
FT   HELIX           16..29
FT                   /evidence="ECO:0007829|PDB:2K5S"
FT   HELIX           32..42
FT                   /evidence="ECO:0007829|PDB:2K5S"
FT   HELIX           44..50
FT                   /evidence="ECO:0007829|PDB:2K5S"
FT   HELIX           61..65
FT                   /evidence="ECO:0007829|PDB:2K5S"
SQ   SEQUENCE   67 AA;  8063 MW;  F74388E5E14F294F CRC64;
     MTKTDYLMRL RKCTTIDTLE RVIEKNKYEL SDDELELFYS AADHRLAELT MNKLYDKIPP
     TVWQHVK